paracrine signaling

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paracrine signaling

[′par·ə‚krēn ‚sig·nəl·iŋ]
(physiology)
Signaling in which the target cell is close to the signaling cell and the signal molecule affects only adjacent target cells.
References in periodicals archive ?
This experiment aimed to determine whether SASP from H2O2 treated MSCs having silenced FLNB or CD13 were still able to induce senescence in healthy cells by paracrine mechanism.
* They play a key role in intracellular paracrine signaling to direct healing with your own stem cells.
A comparative study of mesenchymal stem cell transplantation with its paracrine effect on control of hyperglycemia in type I diabetic rats.
The physiological, biochemical and bio-molecular properties of EAT and the possible paracrine interactions within the heart have been described in previous studies.6 EAT exists mainly in the atrioventricular and interventricular groove along the major coronary arteries and branches, to a lesser extent in the atrium, right ventricle and the left ventricular free wall that shows extension to the apex.7 The embryological origin of EAT is similar to intra-abdominal visceral adipose tissue.8
paracrine modulation of cardiomyocyte contractility by cardiac
Stem cell transplantation can provide a large number of hepatocyte-like cells, replacing the synthetic and metabolic function required by the normal liver, and change the tissue microenvironment through a paracrine mechanism [9].
This in turn leads to paracrine and autocrine receptor activation, which plays an important role in the resolution of airway inflammation and tissue damage.
In fact, alginate-encapsulated hepatocytes demonstrated higher viability and albumin secretion upon coculture with MSCs thanks to the paracrine effect of their secreted cytokines CCL2, CXCL12, and macrophage migration inhibitory factor (MIF).
Second, our results showed that hAEC-CM could promote proliferation, migration, and tube formation of endothelial cells, suggesting the paracrine effects of hAECs on neovascularization directly.
It should be kept in mind, however, that adipokines are part of large neuroendocrine-immune-metabolic networks, and they exert their effects through complex endocrine, paracrine, autocrine, or juxtacrine crosstalk mechanisms, which should be further investigated with system medicine approaches.
The sad story is that the claims of this study could not be reproduced no matter how the cells were isolated and treated.17 BMCs could have provided paracrine cardioprotective factors to improve the cardiac function.18 What might be the underlying mechanisms are not known.
Somatuline's active substance, lanreotide acetate, is a somatostatin analogue that inhibits the secretion of several endocrine, exocrine and paracrine functions.