Magnetic nanoprobe that is super paramagnetic iron
oxide nanoparticles (SPIONs-C959) bonded with folic acid was produced firstly.
The team, led by Rex Moats, PhD, and Karen Aboody, MD, said their method, which involves "pre-loading" the cells before transplantation with ultra-small, super paramagnetic iron
oxide nanoparticles that can then be detected via magnetic resonance imaging (MRI), has been approved for clinical trials in humans and has the potential to greatly accelerate the search for new treatments for deadly brain tumors and other diseases.
MRI labels include paramagnetic iron
oxide and manganese oxide.
2]-weighted MRI does not use a refocusing pulse, "so the dephasing caused by the paramagnetic iron
is accentuated by the [T*.
For the research reported in PNAS, Yijen Wu, research biologist at the Pittsburgh NMR Center, tagged macrophages with nanometer (USPIO)- or micrometer (MPIO)-sized paramagnetic iron
oxide particles, which are very sensitive to magnetic fields used during MRI.
In particular, dry chemistry coagulation testing at the POC with paramagnetic iron
oxide particles (PIOP) has provided alternatives to testing previously done only in the laboratory and has opened the door to convenient fibrinolytic testing [2-4].
Elaborating on the procedure of the research, Dr Arsalani said, "We first synthesized super paramagnetic iron
oxide nanoparticles by using the common and cost-effective method of co-precipitation in an aqueous environment.
Each TAS PT-One test cartridge contains lyophilized thromboplastin from human placenta, calcium chloride, and buffers coated with paramagnetic iron
oxide particles (PIOP).
The discovery of an interaction between our Paramagnetic Iron
Oxide Particles (PIOP) and the Somagen coated beads was particularly exciting," said Don Mahan Ph.
The main constituent of this drug delivery system is based on polyamidoamine polymers (dendrimer) which are acetylated through a chemical reaction and act as shells for paramagnetic iron