parent compound

parent compound

[′per·ənt ‚käm‚pau̇nd]
(chemistry)
A chemical compound that is the basis for one or more derivatives; for example, ethane is the parent compound for ethyl alcohol and ethyl acetate.
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Indeed, phase I metabolism may generate metabolite(s) with increased, decreased or similar activity to that of the parent compound.
The results showed that parent compound 4-(4'-Bromophenyl)-4-hydroxy piperdine exhibited no inhibitory response whereas significant activity was shown by the compounds, 1-(1''-Adamantan acyl)-4- (4'- bromophenyl)-4-hydroxy piperidinium Hydrobromide (I) This kind of exhibition due to the substitution of adamantane group in molecule and adamantine is responsible for causing the modulation of neurotransmitter Furthermore quarternization with piperidine ring made it more suitable for cholinergic activity [18].
The predictions in OASIS are based on the combination of a toxicodynamic and toxicokinetic model in a single platform, where a mechanistic QSAR model for ER and AR binding affinity is combined with metabolism models [referred to in the QSAR tool as Tissue Metabolism Simulator (TIMES)] to address binding of either the parent compound or its predicted metabolites (Mekenyan et al.
EFSAs expert Panel on Contaminants in the Food Chain (CONTAM) considered information on the toxicity of glycidol (the parent compound of GE) for its risk assessment of GE, assuming a complete conversion of the esters into glycidol following ingestion.
It is often considered the parent compound of several naturally occurring organic compounds.
The majority of these designer drugs are derived from the parent compound cathinone, the active ingredient of the plant khat (Catha edulis).
The new antimalarial drugs were designed by the addition/substitution of different functional groups and molecules in parent compound of pyrimethamine.
This resulting nanomaterial can offer advantages--such as being strong, having an antimicrobial effect or producing a desired color--but it behaves in different and unpredictable ways compared with its unmanipulated parent compound.
In addition, the osmolal gap, a reflection of the presence of the parent compound, can be diminished if the patient presents late and has already metabolized most of the parent compound into its organic-acid metabolites.
The cyclized compound, 3-amino-6-methyltetrahydro-2H-pyran-2-one (2) showed better lipid lowering and antioxidant profile than the parent compound I.
Based on the MS data, Compound 2 was tentatively assigned as vinblastine, which is a starting material in the synthesis, and Compound 3 was determined to be an isomer of the parent Compound 1.
For example, for steroids like Stanozolol or Nandrolone, the parent compound is not detected in a urine sample or reported by the laboratory, but the steroids' metabolites are.