PPIs bind to, and irreversibly inhibit, the proton pump in the parietal cells
of the gastric mucosa, therefore their therapeutic effect lasts until the proton pumps are replaced as part of normal cellular turnover.
All PPIs are substituted derivatives of benzimidazole, which is pharmaceutically inactive compound with short half-life of (0.6 - 1.9 hours), needs acidic environment of the secretory canaliculus of the stimulated parietal cells
, with a pH of approximately 1.0.
We measured the levels of b2-glycoprotein I, anti-antinuclear anti-gastric parietal cell
, anti-Langerhans cell, anti-thyroperoxidase, anti-thyroglobulin, GMI, and anti-cardiolipin antibodies in 4 patients with increased levels of GADA.
The primary parietal cells
divided repeatedly through periclinal and anticlinal divisions to form the subepidermal endothecium and two middle layers (Fig.
also reported higher RDW in PA.23 All patients with PA were positive for parietal cell
and intrinsic factor antibodies.
of patients 0-50 8 51-100 15 101-150 9 151-200 9 201-250 2 251-300 4 >300 3 Table 8: Anti-intrinsic Factor Blocking Antibodies (AIFAB) and Anti- Parietal Cell
Antibodies (APCAB) as observed in 50 Parameters No.
Mode of action 1 Proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the [H.sup.+]/ [K.sub.+] -ATPase in the gastric parietal cell
. Omeprazole blocks the final step in acid production, thus reducing gastric acidity.
The clinical and pathological significance of gastric parietal cell
Histamine is produced from mast cells or histamine-containing cells similar to mast cells, which lie close to the parietal cells
. There is a steady basal release of histamine, which can be increased by gastrin and acetylcholine.
These may include gastrin level measurements or assays for intrinsic factor or parietal cell
antibodies, or transcobalamin assays.
The parietal tissue is derived from the archespore, which divides to form a proximal megasporocyte and a distal parietal cell
(which may or may not divide further) (e.g., Davis, 1966), although in practice this cell division is rarely observed.
Research is under way on laparoscopic inguinal herniorrhaphy, parietal cell
vagotomy, pyloroplasty, and esophageal reflux operations.