lipodystrophy

(redirected from partial lipodystrophy)
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lipodystrophy

[‚lip·ə′dis·trə·fē]
(medicine)
A disturbance of fat metabolism in which the subcutaneous fat disappears over some regions of the body, but is unaffected in others.
References in periodicals archive ?
Akcea and Isis initiated a Phase 3 study of volanesorsen in patients with familial partial lipodystrophy.
2001) and can cause an inherited disorder called familial partial lipodystrophy (FPLD), which is characterized by abnormal body fat distribution.
In 2002, a mutation called PPAR-gamma was linked to another type of familial partial lipodystrophy.
Previous studies mapped mutations in a family prone to partial lipodystrophy to a region on chromosome 1 containing about 120 genes.
Findings from the first poster titled, "Metabolic Effects of Metreleptin Treatment in Familial Partial Lipodystrophy (FPL)," included data from an ongoing expanded access protocol of metreleptin administration in patients with rare forms of inherited or acquired lipodystrophy.
Akcea's most advanced program, volanesorsen, is in Phase 3 development to treat patients with ultra-orphan lipid disorders that are characterized by extremely high triglycerides and ApoC-III, including familial chylomicronemia syndrome (FCS) and familial partial lipodystrophy (FPL).
NASDAQ: ISIS) and its wholly owned subsidiary, Akcea Therapeutics, today announced the start of a Phase 3 study to evaluate the efficacy and safety of volanesorsen in patients with familial partial lipodystrophy (FPL).

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