pemphigoid


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pemphigoid

[′pem·fə‚gȯid]
(medicine)
An autoimmune skin disorder resembling, but histologically and clinically distinct from, pemphigus and characterized by bloody blisters, especially on the trunk and limbs.
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There was a study by Tukaj et al., which he conducted among bullous pemphigoid patients and healthy subjects but the results showed no significant difference in vitamin D serum levels.
Diagnosis starts with obtaining detailed medical history along with thorough clinical examination to rule out other more serious diseases such as blood dyscrasias, mucous membrane pemphigoid, epidermolysis bullosa, linear IgA and dermatitis herpetiformis.
Keywords: Orf, bullous pemphigoid, orf-induced immunobullous disease.
'This is an extremely important milestone for the bertilimumab program, as we have secured clinical manufacturing not only for our planned pivotal phase 2/3 trial in bullous pemphigoid, but for future trials in ulcerative colitis, asthma and other indications,' commented Tony Fiorino, MD, PhD, Chief Medical and Operating Officer of Immune.
Its lead product candidate, bertilimumab, is being development for bullous pemphigoid and ulcerative colitis.
In one study, labial biopsies obtained from two patients revealed chronic and acute inflammatory changes, indicating that inflammation may play a role in the formation of labial adhesion in hypoestrogenic women.6 However, it may also occur in the presence of normal estrogen levels.7 In women of reproductive age; female circumcision, herpes simplex, diabetes, pemphigoid, caustic vaginitis, poor hygiene, trauma related to sexual abuse or a fall and lichen sclerosis are reported to be the causes of labial adhesion.1,8 In the present case, we excluded hypoestrogenemia as a causative factor since the patient's estrogen levels were normal.
Burkhart, RDH, BS, NMEd, EdD, received the 2017 Dental Professional of the Year Award from the International Pemphigus & Pemphigoid Foundation (IPPF).
Pemphigoid diseases are a heterogeneous group of chronic autoimmune disorders that are characterized by autoantibodies directed against various structural proteins of the hemidesmosomes, resulting in epithelial detachment (18).
The lesion is a rare in appearance or occurrence in oral cavity and many a times, it is confused with various systemic disorders such as mucous membrane pemphigoid, epidermolysis bullosa, and herpetiform dermatitis.