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An acute or chronic disease of the skin characterized by the appearance of bullae, which develop in crops or in continuous succession.



a chronic disease characterized by a crop of blisters, or bullae, having a flaccid covering and serous-hemorrhagic contents; the blisters form on the apparently intact skin or mucosa of the oral cavity, larynx, eyes, and genitals. The blisters rapidly enlarge and multiply, bursting to form extensive ulcerated surfaces. The patient’s general condition is disturbed; there is general weakness and elevation of body temperature. Infection of the mouth and larynx makes food intake difficult.

The causes of pemphigus have not been conclusively determined. The disease usually afflicts middle-aged and elderly persons. The mechanism of formation of pemphigus vulgaris is acantholysis, a type of degenerative change in epidermal cells. It involves the dissolution of the intercellular bridges, degenerative change of the nuclei, and loss of part of the cell protoplasm. As a result, communication between the layers of epidermis is disrupted. In other forms of pemphigus, the blisters form as a result of an inflammatory process.

Pemphigus vulgaris progresses gradually, and cachexia develops. The prognosis for persons suffering from other forms of pemphigus is relatively favorable. Treatment includes the ingestion of hormonal preparations, antimicrobial agents, or analgesics. Disinfecting solutions may be applied externally.


References in periodicals archive ?
Burkhart and Rees are both members of the IPPF Dental Advisory Council, providing feedback to the IPPF Awareness Program, which aims to reduce pemphigus and pemphigoid diagnostic delays.
Skin bullous disease, pemphigus vulgaris, bullous pemphigoid, pemphigus foliaceus.
4%) dental ulcer, pemphigus vulgaris, lichen planus and follicular tonsillitis respectively.
Both our cases were immunocompromised patients on treatment for pemphigus vulgaris and Still's disease.
Prednisone 100 mg/d was started for treatment of pemphigus, and 1 week later with a maintenance dose 60 mg/d.
Immunodiagnosis of pemphigus and mucous membrane pemphigoid.
Of the 22 cases, maximum cases were of Pemphigus group (i.
My pemphigus was proving very difficult to treat but Mr Snowden persisted and worked at it until he got it under control and whenever I needed help he was always there for me.
The report provides a snapshot of the global therapeutic landscape of Pemphigus
Paraneoplastic pemphigus with fatal pulmonary involvement in a woman with a mesenteric Castleman tumour.
Nursing diagnoses in pemphigus vulgaris: A case study.
Only between one and five people in a million in the country will get pemphigus vulgaris (PV) each year.