penicillamine


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Related to penicillamine: penicillin

penicillamine

[‚pen·ə′sil·ə‚mēn]
(pharmacology)
C5H11NO2S The most characteristic degradation product of penicillin-type antibiotics; used as a chelating agent, as a drug to reduce cystine excretion in cystinurea, and in the treatment of rheumatoid arthritis.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Pulmonary hemorrhage is a rare complication of DI-ILD, but is seen with anticoagulants, anti-fungals (amphotericin B), chemotherapeutic agents (mitomycin, Ara-C, high-dose cyclophosphamide), cardiac medications (amiodarone) and immunosuppressive agents (penicillamine).1 Some of these patients will present with hemoptysis in addition to acute dyspnea--penicillamine is particularly implicated in this finding.
There are six agents available to treat heavy metal (arsenic, gold, iron, lead, and mercury) intoxication: de-ferasirox (iron), deferoxamine (iron), dimercaprol (arsenic, gold, lead, and mercury), edetate calcium disodium (lead), penicillamine (copper and mercury), and succimer (lead).
The goal of this paper was the kinetic modeling of the decomposition of (I) to determine the elimination rate constant of penicillamine. The study also aimed to investigate the exchange reaction of the thiol ligands of (I) (as an efficient exogenic donor of NO [14]) for glutathione, as this is an important process for a possible exchange reaction of the NIC thiol ligand with biologically significant thiols in vivo.
Ltd, Japan], Ketamine [Rotexmedica Co., Germany], Penicillamine and L-hydroxyproline [the latter three from Sigma Chemical Co, England] were used.
It is often an associated condition with hypersensitivity pneumonia and as the result of medications such as penicillamine.
N-ACETYL CYSTEINE AND PENICILLAMINE INDUCE APOPTOSIS VIA THE ER STRESS RESPONSE-SIGNALING PATHWAY.
"They are often misdiagnosed, or treated with drugs used in adults such as Plaquenil, hydroxychloroquine, sulfasalazine, penicillamine, and steroids, which have been shown in a meta-analysis to be no better than placebo in children."
Level two is antimalarials and gold therapy, and the third level penicillamine, methotrexate and sufasalazine.
The therapeutic measures for this disorder revolve around chelating the excess copper using chelating agents such as tetrathiomolybdate, trientine and penicillamine.
An excretion of urinary copper >25 [micro]mol/day after penicillamine challenge was found to be useful in confirming symptomatic WD patients with active liver disease (sensitivity 92%) but unreliable for excluding WD in asymptomatic siblings (sensitivity 46%) (15).
Common drugs associated with blood dyscrasias Aplasia Agranulocytosis Thrombo- Haemolytic cytopenia anaemia Gold Anti-thyroid Gold Beta-lactams drugs Choramphenicol Phenylbutazone Heparin Quinine/ quinidine Penicillamine Sulphonamide Quinine/ Thiazides quinidine NSAIDs Clozapine Sulphonamides Sulphonamides Sulphonamides Phenothiazines Anticonvulsants NSAIDs Anti-thyroid Mianserin NSAIDs Rifampicin drugs Sulphonylureas NSAIDs Diuretics Isoniazid Phenothiazides Beta-lactams Rifampicin Phenothiazines Allopurinol Captopril Sulphonylureas Sulphonylureas [H.sub.2]- Cimetidine Nomifensine antagonists
Functional procedures, such as penicillamine provocation for nutritional and TM status, allow a non-invasive, clinical window on cellular mineral and cellular buffering competencies.