has been used in mercury poisoning (one report), in addition to its indication as a chelating agent for copper in the treatment of Wilson's disease.
and L-hydroxyproline [the latter three from Sigma Chemical Co, England] were used.
The patient recovered sufficiently after treatment with penicillamine
and plasmapheresis to permit discharge after 12 days.
N-acetyl cysteine (NAC) and penicillamine
(PEN) have been shown to induce apoptosis in multiple types of human cancer cells; however, the molecular mechanism underlying this activity is unclear.
Low-dose methotrexate (5 to 15 mg once weekly) is now being used more often, before therapy with gold salts or penicillamine
, with improvement in symptoms, although the mechanism of action is debatable.
This process of endothelial activation by copper can be reversed using chelating agents like penicillamine
(59), a property that is widely exploited in designing therapeutic regimens (see section below).
The only other disease-modifying antirheumatic drugs that have been evaluated for the treatment of ankylosing spondylitis in randomized, placebo-controlled trials are penicillamine
(19) and auranofin, (18) and neither were effective.
Therapy involves lifelong administration of either D- penicillamine
or trientine hydrochloride; both of these drugs remove copper deposits by binding to the copper which is removed from the body via the urine.
Functional procedures, such as penicillamine
provocation for nutritional and TM status, allow a non-invasive, clinical window on cellular mineral and cellular buffering competencies.
is being used successfully to slow the progression on the sclerodactyly (see Figure 3).
But the 68 year-old Teesside granddad admits he's one of the lucky ones - because his medication, Penicillamine
, has fought off most of the symptoms.
2]EDTA, citrate, penicillamine
, and 2,3-dimercapto-1-propanol, also known as British AntiLewisite (BAL)] have been shown to increase GI Pb absorption, and in some cases (citrate, penicillamine
, and BAL) this has resulted in an increase in body Pb burden (11).