penicillinase


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penicillinase

[‚pen·ə′sil·ə‚nās]
(biochemistry)
A bacterial enzyme that hydrolyzes and inactivates penicillin.
References in periodicals archive ?
Etest (bioMerieux) was also used to determine the minimum inhibitory concentration (MIC) of penicillin and ampicillin on three isolates classified as penicillinase hyper-producers.
TEM-3 [beta]-lactamases which hydrolyzes broad-spectrum cephalosporins, is derived from the TEM-2 penicillinases by two amino acid substitutions.
Discrepancies between Vitek penicillinase detection and the nitrocefin test have been similarly noted by Ferreira et al, where their study found 52 (91.
Ceftazidime, methicillin, ampicillin, amoxicillin, cloxacillin, penicillin G (benzylpenicillin), penicillinase ([beta]-lactamase) and clavulanic acid were obtained from Sigma (Sigma-Aldrich, UK).
Inhibition of penicillinase by epigallocatechin-gallate resulting in restoration of antibacterial activity of penicillin against penicillinase-producing Staphylococcus aureus.
Resistance to amoxicillin-ticarcillin (by penicillinase production) was detected for 22.
The best-known example of such a combination is the comedication of the [beta]-lactam antibiotic (BLA) penicillin with clavulinic acid (sulbactam or tazobactam) which successfully antagonizes the penicillinase resistance (Lee et al.
Resistance was caused when the organism produced a penicillinase enzyme (beta-lactamase) that deactivated penicillin by cleaving the beta-lactam ring.
ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.
The most successful strategy that has been adopted to overcome the resistance to penicillinase is by administering clavulinic acid, with the drugs sulbactam and tazobactam (Lee et al.
aureus (strains ATCC 6538, 7+ penicillinase producer and 8 - penicillinase non-producer), S.

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