penicillinase


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penicillinase

[‚pen·ə′sil·ə‚nās]
(biochemistry)
A bacterial enzyme that hydrolyzes and inactivates penicillin.
References in periodicals archive ?
Staphylococcal resistance to penicillin is mediated by penicillinase (a form of [beta]-lactamase) production: an enzyme that cleaves the P-lactam ring of the penicillin molecule, rendering the antibiotic ineffective.
Inhibition of penicillinase by epigallocatechin gallate resulting in restoration of antibacterial activity of penicillin against penicillinase-proclucing Staphylococcus aureus.
Figure 2: Cephalosporinase/penicillinase induced neutralization of 13 [beta]-lactam antibiotics which inhibit growth of Kocuria rhizophila ATCC 9341 on TSA contact plates Reference without With cephalosporinase cephalosporinase and penicillinase or penicillinase (medium contains (medium contains lecithin end Tween 80) lecithin.
It holds the advantage of being a superb inducer of the mecA gene and is less affected by penicillinase hyper-producing isolates than oxacillin.
37]Ra in stick penicillinase ELISA for the detection of seroreactivity in pulmonary and extrapulmonary TB, ES-31 showed good potential in detecting IgG antibody in TB Lymphnode, Tubercular meningitis and pulmonary TB.
aureus that produced penicillinase, a [beta]-lacta mase that deactivates penicillin by cleaving a bond in the b-lactam ring.
aureus produced a factor called penicillinase (or beta-lactamase), which degraded penicillin and decreased its effectiveness in treating Staph infections.
This new drug was a synthetic penicillin that the penicillinase enzyme could not recognize.
This germ could produce an enzyme, penicillinase, that destroyed the penicillin molecule.
In the gonococci, the chromosomally mediated expression of multiple resistance genes and the production of the penicillinase plasmid TEM-1 [beta]-lactamase are 2 independent mechanisms involved in a susceptible-to-resistant strain switch.
Penicillin and cephalosporins are not recommended for initial treatment due to the demonstration of a cephalosporinase and an inducible penicillinase in the anthrax genome.

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