pentasaccharide

pentasaccharide

[‚pen·tə′sak·ə‚rīde]
(biochemistry)
A carbohydrate which, on hydrolysis, yields five molecules of monosaccharides.
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Routinely, unfractionated heparin (UHEP) as anticoagulant drug has been primarily employed in clotting disorders, which inhibits thrombin and activated factor X mediated by antithrombin (AT) due to its specific pentasaccharide sequence (Mourao et al.
Chemically the N-glycans are generally characterised by a common pentasaccharide core, consisting of an N,N-diacetylchitobiose unit extended with a branched tri-mannosyl entity as shown in Fig.
Fondaparinux is a synthetic pentasaccharide that is difficult to manufacture on a commercial scale.
Fondaparinux is a synthetic pentasaccharide which is difficult to manufacture on a commercial scale.
It is a Hetropolysacharide associated with a primary structure which is consist of repetitive Pentasaccharide units and are formed by two units of glucose, mannose units and one unit of glucuronic acid (a carboxylic acid similar to glucose).
The backbone of the polysaccharide chain consists of repeating pentasaccharide units formed by two glucose units, two mannose units, and one glucuronic acid unit.
the pentasaccharide) led to the development of fondaparinux, a synthetic antithrombotic drug that mimics the essential pentasaccharide sequence (3).
Although not formally approved for this indication by the FDA, there are an increasing numbers of anecdotal reports of patients with HIT being successfully managed with the pentasaccharide, fondaparinux, in lieu of a direct thrombin inhibitor (DTI).
The unboiled rCTB demonstrated a strong affinity for GM1-ganglioside (Figure 4), indicating that the expressed rCTB conserved its antigenic sites which are necessary for its binding to the GM1 pentasaccharide and also confirmed proper folding of the recombinant protein resulting in the functional pentameric structure.
Thromboprophylaxis should include the following modalities: avoiding of patients' immobilization, early physical therapy, providing of adequate quantities of fluids, anticoagulation therapy (unfractionated heparin, low-molecular-weight heparin, Fondaparinux a synthetic pentasaccharide Factor Xa inhibitor), and mechanical modalities (e.
Turpie AGG, Gallus AS, Hoek JA, for the Pentasaccharide Investigators.