The backbone of the polysaccharide chain consists of repeating pentasaccharide
units formed by two glucose units, two mannose units, and one glucuronic acid unit.
Effects of pentasaccharide
(Fondaparinux) and direct thrombin inhibitors on coagulation testing.
13: Low Molecular Weight Heparin or Pentasaccharide
Indications for VTE Treatment 133 Table 6.
) led to the development of fondaparinux, a synthetic antithrombotic drug that mimics the essential pentasaccharide
Fondaparinux (Arixtra) is a synthetic sulfated pentasaccharide
that inhibits factor Xa indirectly by binding to antithrombin III.
Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide
macrolactone from the European Convolvulaceae Calystegia soldanella.
Elective Surgery Study (EPHESUS) Steering Committee.
20,21) Fondaparinux is a synthetic pentasaccharide
that inhibits factor Xa, and therefore could be used in patients known to be hypersensitive to LMWH preparations.
A particular unique, highly sulphated pentasaccharide
sequence that is present in 30% of heparin molecules accounts for the anticoagulant effect of heparin.
Fondaparinux is a heparin pentasaccharide
analogue that does not bind to platelet-factor 4 and thus should not cause HIT.
Mario Pinto, from Simon Fraser University, David Bundle and Mary Chervenak from the University of Alberta, and Nand Vyas, Meenakshi Vyas and Florante Quiocho from Baylor College of Medicine in Houston, TX, have shown that the binding modes of the pentasaccharide
that elicits the immune response in the first place are significantly different from the synthetic octapeptide.