It is especially helpful for discriminating between glucose metabolism through the oxidative and nonoxidative branches of the pentose phosphate pathway
(see sidebar, p.
The oxidative pentose phosphate pathway
and the malate shunt also contribute flexibility (and complexity).
It is possible that pentose phosphate pathway
or other NADPH-generation pathways are increased in response to oxidative stress in acute toxoplasmosis (on day 7 after infection).
This may be done by the activation of reductive pentose phosphate pathway
(PPP) by high-dose thiamine therapy that would increase transketolase (TK) activity and stimulate the conversion of glyceraldehyde-3-phosphate (GA3P) and fructose-6-phosphate (F6P) to ribose-5-phosphate (R5P), thus reducing the risk of the development of diabetic complications.
In this approach, we block three of the metabolic pathways in the cancer cell: (1) the efflux of lactic acid, (2) glutamine use, and (3) the pentose phosphate pathway
(an alternative to glycolysis).
The activity of glucose-6-phosphate dehydrogenase was decreased which slows clown the pentose phosphate pathway
in diabetic conditions (Abdel-Rahim et al.
The increase in glycolysis activates the enzyme fructose 1,6 diphosphatase which activates the pentose phosphate pathway
Metabolic network of Corynebacterium glutamicum consists of the EMP pathway, TCA cycle, Pentose phosphate pathway
and gluconeogenesis to represent the central metabolism (Fig.
Substances stimulating glucose catabolism by the oxidative reactions of the pentose phosphate pathway
in human erythrocytes.
This enzyme is part of the pentose phosphate pathway
and is dependant on thiamin.