Cox, "Glycolysis, gluconeogenesis and the pentose phosphate pathway
," in Principles of Biochemistry, pp.
Alterations in the pentose phosphate pathway
(PPP) and their significance in clear-cell RCC pathogenicity
In the case of fructose, the pancreatic cancer cells used the sugar in the transketolase-driven non-oxidative pentose phosphate pathway
to generate nucleic acids, the building blocks of RNA and DNA, which the cancer cells need to divide and proliferate.
G6PD is the first enzyme in the pentose phosphate pathway
. Its most important function is to reduce nicotinamide adenine dinucleotide phosphate (NADP) to NADPH.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency: G6PD (EC18.104.22.168) is an enzyme expressed in all tissues, where it catalyses the first step in the pentose phosphate pathway
Transketolase plays a role in a chain of reactions called the pentose phosphate pathway
, whereas PDH and KGDH are involved in glycolysis and the citric acid cycle.
Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway
and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis.
Specific topics include parallel Monte Carlo simulation of HIV molecular evolution in response to immune surveillance, differential evolutionary algorithms for in vivo dynamic analysis of glycolysis and pentose phosphate pathway
Pentose phosphate pathway
enzymes and glucose oxidation in fluoride-fed rats.
The first 24 are the same map of glycogen[right arrow]glucose-6-phosphate[right arrow]pyruvate[right arrow]Krebs cycle with pentose phosphate pathway
and fatty acids.
Possible functions of this oxidative pentose phosphate pathway
, in addition to production of NADPH, are production of ribose-5P and erythrose-4-P, which are important precursors in biosyntheses.
The pentose phosphate pathway
(PPP) is a major glucose catabolic pathway parallel to glycolysis that is responsible for synthesis of the nucleotide precursor ribose and nicotinamide adenine dinucleotide phosphate (NADPH) required for glucose metabolism.