Peptidase


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Related to Peptidase: signal peptidase

peptidase

[′pep·tə‚dās]
(biochemistry)
An enzyme that catalyzes the hydrolysis of peptides to amino acids.

Peptidase

 

any one of a group of enzymes of the hydrolase class. Peptidases split off one amino acid at a time from either the carboxylic or the aminic end of protein and peptide molecules. Accordingly, they are classed as either carboxypeptidases or aminopeptidases. Dipeptidases hydrolyze dipeptides.

References in periodicals archive ?
Discovery and preclinical profile of saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of Type 2 diabetes.
The online version will have the enhanced options including online multimedia, cross-referencing capabilities, integrated online delivery and closer integration with the online MEROPS database of peptidases and their inhibitors.
To get a fuller picture of the structure of the peptidase, Illinois graduate student Vinayak Agarwal crystallized MccF while it was bound to other molecules, including the antibiotic.
4] Human genes: AR, androgen receptor; PIK3CA, phosphoinositide-3-kinase, catalytic, alpha polypeptide; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; BRAF, v-raf murine sarcoma viral oncogene homolog B1; KLK3, kallikrein-related peptidase 3; KLK2, kallikrein-related peptidase 2.
We have examined the prognostic value of alternative mRNA variants of the KLK8 [6] (kallikrein-related peptidase 8) gene.
Topics of the ten papers include the biodistribution of metal ions, medicinal inorganic chemistry, the chemical toxicology of metals and metalloids, charge transport in biological molecules, bioorganometallic chemistry, interactions with metal ions, the bioorganic side of nucleic acid chemistry, nuclease and peptidase models, metalloporphyrins and metalloporphyrinoids, model complexes for enzymes containing vanadium, model complexes for enzymes containing molydbenum and tungsten, structural and functional models for oxygen-activated nonheme iron enzymes, model chemistry of iron-sulfur protein active sites and model complexes of enzymes containing nickel.
Since the feat would probably require some sort ofpeptide-destroying enzyme, or peptidase, researchers refer to this approach as enzymatic therapy.
For example, some regulatory peptides are metabolized/ modulated by membrane-bound peptidases such as dipeptidyl peptidase IV (DPPIV or CD26) and angiotensin-converting enzyme (22-25).
Topics of the 15 chapters include modification of peptides and other drugs using lipoamino acids and sugars, synthesis of cell-penetrating peptides for cargo delivery, expressed protein ligation for protein semi-synthesis and engineering, quenched fluorescent substrate-based peptidase assays, cyclic peptide libraries, and peptide bioconjugates.
The dipeptidyl peptidase 4 (DPP-4) inhibitor, in a single 5-mg tablet formulation, is indicated for improving blood glucose control in adults with type 2 diabetes in combination with diet and exercise.
2]-M), which does not block the active site or peptidase activity of proteinases bound to it (18-24).