peptide synthetase

Also found in: Medical.

peptide synthetase

[′pep‚tīd ′sin·thə‚tās]

(biochemistry)

A ribosomal synthetase that catalyzes the formation of peptide bonds during protein synthesis.

References in periodicals archive ?

Genetic analysis of the peptide synthetase genes for a cyclic heptapeptide microcystin in Microcystis spp.

Diversity of microcystin-producing genotypes in Brazilian strains of Microcystis (Cyanobacteria)/Diversidade de genotipos produtores de microcistinas em linhagens brasileiras de Microcystis (Cyanobacteria)

It was proposed that a polyketide synthase (PKS) catalyzes the condensation of a chlorobutanoyl intermediate with an acetate unit, and subsequently with the clyclohexenyl-alanine amino acid arising from the shikimate pathway which is incorporated into the product by the activity of a non-ribosomal peptide synthetase (NRPS).

Biotechnology and biochemistry of marine natural products

Microcystin is a hepatotoxin produced by a non-ribosomal pathway through a polyketide synthase/non-ribosomal peptide synthetase (PKS/NRPS) complex known as microcystin synthetase, which is responsible for the incorporation of amino acids in the peptide chain (Kleinkauf and von Dohren, 1996; Dittmann et al., 1997).

Toxic cyanobacteria in reservoirs in northeastern Brazil: detection using a molecular method/Cianobacterias toxicas em reservatorios do nordeste do Brasil: deteccao utilizando metodo molecular

The BB and many of the siderophores are produced non-ribosomally by large, multi-domain enzymes termed as non-ribosomal peptide synthetases (NRPS) that can assemble peptides of wide structural diversity and broad biological activity [16].