perianal

(redirected from perianal fistula)
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Related to perianal fistula: Perianal abscess

perianal

[¦per·ē′ān·əl]
(anatomy)
Situated or occurring around the anus.
References in periodicals archive ?
A single injection of Cx601 was statistically superior to placebo in achieving combined remission at week 24 of complex perianal fistulas in Crohn's disease patients with inadequate response to previous therapies, including anti-TNFs
Cx601 is in Phase III for the treatment of complex perianal fistulas in Crohn's disease patients.
The latest addition to this therapy is some course of immunosuppressive drugs to address the immune mediated issues that have recently been incriminated as part of the pathogenesis of perianal fistulas.
Cx601 offers a novel mechanism of action to treat perianal fistulas, for which there is not any cure yet, said Maria Pascual, vice president Regulatory Affairs & Corporate Quality at TiGenix.
The agreed pivotal trial in complex perianal fistulas in Crohn's disease patients will evaluate the efficacy and safety of Cx601 24 and 52 weeks after a single-dose administration of the product.
In December last year, TiGenix submitted to the FDA the required documentation for a Special Protocol Assessment (SPA) of its pivotal phase III trial design for Cx601 in the treatment of complex perianal fistulas in patients with Crohn s disease in the US.
Lonza will utilise our manufacturing knowledge and world class quality systems to manufacture this potentially life- changing product for Crohn s disease patients with complex perianal fistulas.
For perianal fistulas, tacrolimus patients had a significantly higher rate of response to treatment, compared with placebo patients--9 of 20 vs.
Up to one third of patients with Crohn's disease suffer from draining perianal fistulas, a chronic and debilitating condition that significantly affects their quality of life," said Professor Stephen Hanauer, M.
Perianal fistulas responded better to infliximab than did fistulas at other anatomic sites; complete responses were documented in four of nine patients.