According to ANI measurement; dexmedetomidine and remifentanil are both sufficient and efficacious agents for perioperative analgesia
in hysteroscopy patients.
Optimized perioperative analgesia
reduces chronic phantom limb pain intensity, prevalence, and frequency.
Tsolakis et al., "Optimized perioperative analgesia
reduces chronic phantom limb pain intensity, prevalence, and frequency," Anesthesiology, vol.
Different aetiologies of post-laparoscopy pain are recognised and many modes of perioperative analgesia
have been proposed to improve post-operative pain (Mouton et al 1999, Bayar et al 2008, Ng et al 2008, Costello et al 2009).
Based on the limited data available; intrathecal midazolam appears to improve perioperative analgesia
and reduce nausea and vomiting during caesarean delivery.
We showed that adding dexamethasone to epidural bupivacaine significantly prolongs the duration of perioperative analgesia
, in addition to producing earlier onset of action.
Considering above facts the study was designed using low dose of bupivacaine with low dose of fentanyl in order to assess the quality of subarachnoid block, hemodynamic stability, perioperative analgesia
, quality of motor & sensory block, perioperative sedation and any ADRs in patients undergoing major gynaecological surgeries.
COX-2s may be useful for perioperative analgesia
in patients with a bleeding disorder or when surgical blood loss is expected to be high.
Peripheral nerve blocks may provide ideal perioperative analgesia
for these patients because they are not associated with haemodynamic instability or depression of pulmonary function (3,9).
Weigl et al  in a similar study, concluded that combination of Morphine 100 [micro]g and 25 [micro]g Fentanyl to different doses of Bupivacaine, shortens the incision time and much improved the perioperative analgesia
. With intrathecal fentanyl, pain relief is obtained within 10 minutes while intrathecal morphine takes about 60 minutes for onset of its analgesic action.
One of the main components of early recovery after surgery programs is establishment of adequate perioperative analgesia
. Historically, systemic administration of opioid drug groups has been the cornerstone of acute postoperative pain control but trends have changed towards increased utilization of regional anesthetic and analgesic techniques during the last few decades.
Postoperative changes in prothrombin time following hepatic resection: implications for perioperative analgesia
. Anaesth Intensive Care 2006; 34:438-443.