peripheral sink

peripheral sink

[pə′rif·ə·rəl ′siŋk]
(geology)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Finally, the antibodies would not cross the blood-brain barrier but would bind to the circulating A[beta] molecules present in the plasma of the affected subject, thereby leading to a concentration gradient that ultimately would result in the efflux of A[beta] from the brain into the blood and plasma, a mechanism known as the peripheral sink model (20).
Testing vaccines that are able to induce specific antibodies prior to the manifestation of symptoms may be an alternative to prevent amyloid being deposited in the senile plaques, according to the peripheral sink hypothesis.
The question of geographic clines in age structure is more difficult to address with the available correlative data, Subtle changes in sampling procedure associated with elevation may result in minor variation in observed age ratios, but as I have suggested, the bulk of the regional variance may be caused by the dispersal of yearlings from source populations (high relative abundance) along the Appalachian axis to peripheral sink populations (low relative abundance).

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