permissive cell


Also found in: Medical.

permissive cell

[pər′mis·iv ′sel]
(virology)
A cell that supports replication of a virus.
References in periodicals archive ?
Production of AAV vectors requires the introduction of several elements into a permissive cell -- the AAV vector and gene of interest, AAV rep and cap genes and a helper virus.
The components required to manufacture an AAV vector include a permissive cell in which to grow the vector, a "rep" gene which allows the vector to be produced in quantity, a "cap" gene which is needed to form the three dimensional viral vector particles containing the therapeutic gene to be delivered, promoter sequences required to turn on the rep and cap genes, and a helper virus, such as adenovirus, which facilitates production of the vector.
After following virus growth in all permissive cells for another 20 h, we harvested supernatants and, to confirm the production of infectious virus particles, we titrated the supernatants by using a plaque assay in Vero cells.