Dengue viruses replicate well in C6/36 cells and in other mosquito lines, they are presently used as sensitive assays for virus isolation from patients, and Vero are also permissive cell
The HEK293-FT cell line was selected as a standard permissive cell
line for its high transfection rate (20), (24)
Figure 17.2 in Basic Virology , illustrating the replication cycle of the closely related SV40 in a permissive cell
, shows no viral integration but provides no references to associated experimental evidence.
The higher load and longer detection of Zika virus RNA in this compartment might be attributable to Zika virus replication in permissive cells
of the skin (e.g., human dermal fibroblasts and epidermal keratinocytes); capillaries; or both (6).
A primary difficulty in modifying permissive cells
for the strategies mentioned above lies in their "personalization" in that permissive cells
of each patient must be collected and modified instead of manufacturing and using the same type of drug, as in traditional therapies.
In permissive cells
, in fact, the JCV entry into the nucleus is followed by the transcription of the early gene TAg.