pernicious anemia


Also found in: Dictionary, Thesaurus, Medical, Legal, Acronyms, Wikipedia.
Related to pernicious anemia: iron deficiency anemia, aplastic anemia

pernicious anemia:

see anemiaanemia
, condition in which the concentration of hemoglobin in the circulating blood is below normal. Such a condition is caused by a deficient number of erythrocytes (red blood cells), an abnormally low level of hemoglobin in the individual cells, or both these conditions
..... Click the link for more information.
.

pernicious anemia

[pər′nish·əs ə′nēm·ē·ə]
(medicine)
A megaloblastic macrocytic anemia resulting from lack of vitamin B12, secondary to gastric atrophy and loss of intrinsic factor necessary for vitamin B12 absorption, and accompanied by degeneration of the posterior and lateral columns of the spinal cord.
References in periodicals archive ?
Role of Helicobacter on infection in pernicious anemia 2000 Dec;32(9):756-62.
In one study, 64 patients receiving 500 mcg or 1,000 meg of [B.sub.12] orally daily for pernicious anemia all had normal serum [B.sub.12] levels, normalization of hemoglobin levels, and no neurologic complications at follow-up through 5 years.
Pernicious anemia has also been reported among Indians, though rarely: most of the publications describe isolated cases of them.
Autoimmune atrophic gastritis is the most frequent cause of pernicious anemia in temperate climates.
In the western countries, pernicious anemia is the most common form of vitamin B12 deficiency.
If an image of an elderly patient with pernicious anemia is the first thing that comes to mind when you think of [B.sub.12] deficiency, take note: That image could obfuscate a more common case of [B.sub.12] deficiency--one caused by food-[B.sub.12] malabsorption.
AGPA are a marker of autoimmune gastritis whereas intrinsic factor antibodies are associated with pernicious anemia. The progression of chronic atrophic gastritis to pernicious anemia may occur over time and may take 20 to 30 years before this may happen.
In particular, patients with pernicious anemia, possibly the commonest type of cobalamin deficiency in developed countries, require either massive doses of oral vitamin [B.sub.12] or parenteral replacement therapy (3-5).
and Canadian authorities are hesitant to add more folic acid to flour is because too much folic acid may camouflage vitamin [B.sub.12] deficiency (pernicious anemia), which largely affects older people, not pregnant women.
Robert Stokstad, the "father" of folic acid research, belonged to one of two in teams in the early 1940s vying to identify the dietary factor responsible for pernicious anemia. Dr.
We also know that mostly the elderly are vulnerable to pernicious anemia, the rare [B.sub.12] deficiency anemia.
Minot and Murphy had demonstrated that there was a dietary factor in liver that reversed the onslaught of pernicious anemia (see 1926).