Five genes involved in thioredoxin-related antioxidant responses are activated by Nrf2, including peroxiredoxin-1 and -6 which destroy peroxynitrite
, an extremely reactive oxidant responsible for nitrosative stress.
Palmer said Replere is the first antioxidant skin care line that targets the five free radicals that damage and age the skin: peroxyl, hydroxyl, peroxynitrite
, superoxide anion and singlet oxygen.
releases into the organism 5,100 ORAC units of antioxidant power specifically against Peroxyl Radicals (ROO) the most abundant free radical in the human body; plus 17,800 ORAC units of antioxidant power combined against the other four predominant Reactive Oxidant Species (ROS) in the body, Hydroxyl Radicals, Superoxide Anion Radicals, Peroxynitrite
and Singlet Oxygen; plus 75% of Natural Total Polyphenols including the highly valued Anthocyanins and Delphinidins components.
SAC is the most studied compound found in black garlic, he continued, and its antioxidant properties have been reported in several studies to prevent lipid and protein oxidation and nitration, scavenging multiple types of free radicals (superoxide, hydrogen peroxide, hydroxyl and peroxynitrite
In 2004 Japanese researchers found that barley contains a compound that destroys peroxynitrite
, a particularly nasty oxidant that causes cardiovascular, inflammatory and neurodegenerative diseases if left unchecked in the human body.
NO readily reacts with superoxide, oxygen and thiol groups (-SH) to produce a number of other products, such as nitrosothiols (R-SNO), the toxic molecule peroxynitrite
(ONOO-) and nitrites (NOx).
SOD plays a pivotal role in protecting tissues from damage by oxidative stress by scavenging superoxide anions, which prevents the formation of other more potent oxidants such as peroxynitrite
and hydroxyl radicals (3).
11), RNS refers collectively to nitrogen-centered radicals and includes nitric acid (NO), peroxynitrite
(ONOO-), nitrogen dioxide radical (*N[O.
This agent reacts with nitric oxide, forming peroxynitrite
, which reacts with lipids, proteins, and nucleic acids.
Treatment of human Schwann cells with donors of nitric oxide and peroxynitrite
reduced taurine transporter (TauT) expression (by 35[+ or -]5% and 29[+ or -]7% respectively p<0.
Trypanosomatids are exposed to reactive oxygen (superoxide anion radical, hydrogen peroxide, peroxynitrite
and the hydroxyl radical) and nitrogen molecules that are originated from parasite itself as by-product of aerobic metabolism or from the host macrophage defense system (5, 7).
scavenging of flavonoids: structure activity relationship.