phenazine

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phenazine

[′fen·ə‚zēn]
(organic chemistry)
C6H4N2C6H4 Yellow crystals, melting at 170°C; slightly soluble in water, soluble in alcohol and ether; used as chemical intermediate and to make dyes.
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Preadmission medications included amphetamine 30 mg twice daily, lurasidone 40 mg daily, mirtazapine 60 mg every bedtime, perphenazine 4 mg twice daily, and quetiapine 300 mg every morning and 700 mg every bedtime.
Thomas Look, MD, of Dana-Farber/Boston Children's Cancer and Blood Disorders Center, and Jon Aster, MD, PhD, of Dana-Farber Cancer Institute and Brigham and Women's Hospital, suggested that developing medications that activate PP2A, while avoiding perphenazine's psychotropic effects, could help clinicians make much-needed headway against T-cell ALL, and perhaps other tumors as well.
P McEvoy et al, "Effectiveness of olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia after discontinuing perphenazine: a CATIE study," American Journal of Psychiatry, vol.
Medication Lovastatin Placebo group group (number) (number) Haloperidol (10 mg/day) 1 1 Perphenazine (24 mg/day) 4 2 Olanzapine (5-15 mg/day) 7 4 Risperidone (1-6 mg/day) 3 2 Thioridazine (100 mg/day) 1 1 Imipramine (25 mg/day) 1 0 Valproate sodium (200-800 mg/day) 6 3 Lamotrigine (100 mg/day) 0 1 Clonazepam (1.5 mg/day) 1 1 Propranolol (20 mg/day) 2 1 Bupropion 0 1 Clozapine (12.5-25 mg/day) 0 2 Carbamazepine (400 mg/day) 0 2 TABLE 3: The rate of adverse effects in both groups.
However, analytes such as norfloxacin, ofloxacin and lomerfloxacin in their mixture have been determined simultaneously using chemometric method (Huang et al., 2009) and other analytes such as chlorpromazine, perphenazine and acetopromazine were quantified by kinetic wavelength-pair method (Carreto et al., 1997).
Examples of older "typical" antipsychotic medications include chlorpromazine (Thorazine), haloperidol (Haldol), perphenazine (Trilafon) and fluphenazine (Prolixin).
Perphenazine has been used in clinical practice as antipsychotic drugs for more than 60 years, and appears to induce their effects by acting as dopamine receptor antagonist [24].
The study compared the efficacy of multiple atypical medications (i.e., olanzapine, risperidone, quetiapine, and ziprasidone) against the older typical antipsychotic perphenazine in 1,493 adults with schizophrenia.
Antipsychotic Medications, Generic and Brand Names and Typical Tablet Dosage Generic Name Brand Name Tablet dosage range Atypical Risperidone Risperdal 1-3 mg Olanzapine Zyprexa 2.5-10 mg Clozapine Clozaril 25-100 mg Quetiapine Seroquel 25-200 mg Ziprasidone Geodon 20-60 mg Aripiprazole Abilify 5-15 mg High Potency Haloperidol Haldol 0.5-20 mg Typical Pimozide Orap 2 mg Fluphenazine Prolixin 2.5-10 mg Medium Potency Trifluoperazine Stelazine 1-10 mg Typical Perphenazine Trilafon 2-16 mg Thiothixene Navane 2-20 mg Loxapine Loxitane 5-50 mg Low Potency Molindone Moban 5-100 mg Typical Mesoridazine Serentil 10-100 mg Thioridazine Mellaril 10-200 mg Chlorpromazine Thorazine 10-200 mg Adapted from Wilens (1999) and Li, Pearrow, & Jimerson (2010).
Epidemiological studies of women who have received prolactin-releasing drugs such as reserpine and perphenazine have not disclosed increased risk (30).
There are two broad categories of antipsychotics: "first generation" medications such as haloperidol and perphenazine, and the newer class known as "atypicals," such as risperidone.