pertussis


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Related to pertussis: Bordetella pertussis

whooping cough

whooping cough or pertussis, highly communicable infectious disease caused by the bacterium Bordetella pertussis. The early or catarrhal stage of whooping cough is manifested by the usual symptoms of an upper respiratory infection with bronchial involvement. After about two weeks the cough becomes paroxysmal; 10 to 15 coughs may follow in rapid succession before a breath is taken, which is the characteristic high-pitched crowing “whoop.” An attack of coughing is accompanied by a copious discharge of mucus and, often, vomiting. Antibiotics and hyperimmune human serum are valuable in treatment. Rest and proper nutrition (especially if there is frequent vomiting) are important.

Whooping cough is a serious disease, especially in children under four years of age, since it may give rise to such complications as pneumonia, asphyxia, convulsions, and brain damage. For these reasons, it is recommended that all infants be actively immunized beginning at as early an age as possible (one to two months). The whole-cell pertussis vaccine available in the United States since the 1940s (see vaccination) became the subject of controversy when it was learned that a toxin contained in it occasionally caused serious side effects. A newer, acellular vaccine, which uses only the parts of the bacterium that stimulate immunity and is less likely to cause side effects, was approved for use in 1996. Five doses are administered over 4 to 6 years, with the first three doses given by 6 months of age. The acellular vaccine, however, is less persistent than its predecessor. It is now believed that adults whose childhood vaccinations are no longer completely effective and whose symptoms are less diagnostic may be the main carriers for the disease; the number of cases in the United States has increased significantly since the introduction of the acellular vaccine. Booster vaccinations are recommended for 11- and 12-year-olds and adults as a means of ameliorating this situation; persons with routine contact with infants should be vaccinated.

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pertussis

[pər′təs·əs]
(medicine)
An infectious inflammatory bacterial disease of the air passages, caused by Hemophilus pertussis and characterized by explosive coughing ending in a whooping inspiration. Also known as whooping cough.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Pertussis commonly begins with runny nose and mild cough said the health officials.
pertussis also undergoes frequent structural rearrangement (6) that presents unique challenges to thorough investigation of genetic contributions to disease resurgence, limiting assessment of public health strategies.
The researchers found that geometric mean concentrations (GMCs) of neonatal cord pertussis toxin antibodies from the Tdap-exposed group were 47.3 IU/mL versus 12.9 IU/mL in the Tdap-unexposed group.
The disease is registered among those who were not vaccinated against pertussis and those who have not completed the full course of vaccination.
The Results: Of the total of 220 contacts who were tested for pertussis, 86% of the households had at least one adult testing positive.
Pertussis data were collected from 1981 to 2015 from various sources including Annual Health Reports, (7) annual Ministry of Health (MOH) progress reports, ex.
The study also revealed that children ages 10 to 14 and who had been vaccinated against the disease were as susceptible to pertussis as those who had never been vaccinated, which suggested that the vaccine's effectiveness wanes over time.
There are other reasons for the resurgence of pertussis, he noted.
The company said the ARIES Bordetella Assay has been approved by the US FDA for direct detection and identification of Bordetella pertussis (B.
Despite the fact that most countries have adopted extended vaccination programs against the disease, pertussis continues to be a significant public health challenge.
Lessons learned: aP protection is less durable than originally thought, and much pertussis is not in infants, but in the school-age and adolescent populations.