phagolysosome


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phagolysosome

[‚fag·ə′lī·sə‚sōm]
(cell and molecular biology)
An intracellular vesicle formed by fusion of a lysosome with a phagosome.
References in periodicals archive ?
pestis to express various proteins enabling escape of the phagolysosome in a diverse array of phagocytic cells including human macrophages (25-27); and prior associations between Y.
During this interaction, mechanisms related to phagosome formation, phagolysosome activity, production of nitric oxide (NO) and ROS, changes in lipid metabolism, expression of cytokines, and other intracellular processes are triggered by the presence of M.
Finally, (8) fusion with LAMP-1-lysosome and (9) phagolysosome formation with fungal killing occur.
McCormack, "Keratinocyte growth factor administration attenuates murine pulmonary mycobacterium tuberculosis infection through granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent macrophage activation and phagolysosome fusion," The Journal of Biological Chemistry, vol.
(14) The best-known member of the genus is Coxiella burnetii, the causative agent of Q fever, a worldwide zoonotic disease that infects the phagolysosome of macrophages.
marinum), survive in macrophages by preventing both phagolysosome formation [40] and recruitment of LC3 to its phagosome [41].
It not only digests materials phagocytized from exogenous sources (e.g., the formation of phagolysosome) but also plays an important role in the removal of damaged intracellular molecules and organelles (e.g., the formation of autophagosome of the autophagy pathways) [40].
The virB operon is essential for non-opsonized Brucella that continues to live within the phagolysosome and to create a successful intracellular replicative compartment (Lopez-Goni and Moriyon, 2004) and modulates Brucella intracellular trafficking (Comerci et al., 2001; Delrue et al., 2001).
(25) TlyA can orchestrate intra-cellular survival by modulating the phagolysosome maturation especially, during the initial stages of establishment of infection, while other pathogenic factors may come into play at a later point of time for the successful establishment of disease.
These is the case of Enterobacter aerogenes, Aeromonas hydrophila and Legionella pneumophila, which have been observed to survive within vacuoles of Acanthamoeba castellanii, inhibiting the fusion of the phagolysosome [27].
During this time, the bacilli resist the bactericidal mechanisms of the macrophage (phagolysosome) by preventing phagosome-lysosome fusion, multiply in the phagosome, and cause macrophage necrosis [5].
The phagolysosome in the phagocytes of coelomate animals contains a variety of hydrolases, including phosphatases (alkaline and acid), lipases and esterases with varying substrate specificity, and an array of substrate-specific glycosidases (reviewed in: Borregard et al., 1993; Hayhoe and Quaglino, 1994).