phagolysosome


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phagolysosome

[‚fag·ə′lī·sə‚sōm]
(cell and molecular biology)
An intracellular vesicle formed by fusion of a lysosome with a phagosome.
References in periodicals archive ?
14) The best-known member of the genus is Coxiella burnetii, the causative agent of Q fever, a worldwide zoonotic disease that infects the phagolysosome of macrophages.
The virB operon is essential for non-opsonized Brucella that continues to live within the phagolysosome and to create a successful intracellular replicative compartment (Lopez-Goni and Moriyon, 2004) and modulates Brucella intracellular trafficking (Comerci et al.
25) TlyA can orchestrate intra-cellular survival by modulating the phagolysosome maturation especially, during the initial stages of establishment of infection, while other pathogenic factors may come into play at a later point of time for the successful establishment of disease.
These is the case of Enterobacter aerogenes, Aeromonas hydrophila and Legionella pneumophila, which have been observed to survive within vacuoles of Acanthamoeba castellanii, inhibiting the fusion of the phagolysosome [27].
The phagolysosome in the phagocytes of coelomate animals contains a variety of hydrolases, including phosphatases (alkaline and acid), lipases and esterases with varying substrate specificity, and an array of substrate-specific glycosidases (reviewed in: Borregard et al.
2014) Streptolysin O and NAD-glycohydrolase prevent phagolysosome acidification and promote group A streptococcus survival in macrophages.
More specifically, natural resistance associated with macrophage protein 1 (NRAMP1) is the only member of the mammalian SLC11 gene family which contributes to antimicrobial function by extruding from the phagolysosome divalent metal ions (e.
Rhodococcus equi can survive a phagolysossomal environment in macrophages by suppressing acidification of the phagolysosome.
Promastigotes attach to mononuclear phagocytes and are taken up by phagocytosis into a phagosome, which fuse with lysosomes to form the phagolysosome.
Movement by Leishmania away from an extracellular ATP source may be a defensive mechanism allowing this parasite additional time to adapt to the toxic environment in the phagolysosome prior to their initial phagocytosis by neutrophils.