We also found that Lyn plays a major role in phagocytosis by recruiting PI3K and Akt to phagosome
membranes in activated AM.
"Previously, invading microorganisms were thought to be enveloped by the plasma membrane of the macrophage, an immune cell, and isolated into a newly-formed phagosome
for degradation," said Desjardins, Caprion's director of proteomics and associate professor at the department of pathology and cellular biology of Universite de Montreal.
Such an antibody-based reaction in the phagosome
would focus the toxic molecules on the cell's intended target, Lerner points out.
, bacteria are ingested and killed by neutrophils.
PBDs deposits (D) were scattered over the intercellular organelles (N; nucleus, Nu; nucleolus, F; fat droplet, M; mitochondria, ER; endoplasmic reticulum, G; Golgi apparatus, P; phagosome
, and V; villi) causing structural changes.
However, Mtb inhibit phagosome
maturation in macrophages and, along with lysosomal fusion, they can survive intracellularly .
(2013) Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome
Actually, as demonstrated by Mariotti et al., (36) dormant mycobacteria lack the capacity to subvert the host immune system due to its inability to block the phagosome
In particular, the membrane reserve is used by lymphocytes during the pseudopodia formation during migration , phagosome
formation  during the processes of deformation during the blood cells passage through the capillaries .
Escape from the Phagosome
: the explanation for MHC-I processing of mycobacterial antigens.
After the bacteria are phagocytosed, listeriolysin O (LLO), an exotoxin, forms a pore in the membrane of the phagosome
that allows the bacteria to escape into the cytosol of the phagocyte, where it is adapted to grow .
The phagocytosed mycoplasma may not be killed or may show resistant to the microbicidal activity of respiratory burst metabolites in phagosome
or lysozymes in lysosome ofthe chicken macrophages (Green et al., 1991; Klasing, 1998; Lam and Damassa, 2000; Qureshi et al., 2000; Qureshi, 2003).