On the basis of mechanism DDIs are divided into pharmacokinetic and
pharmacodynamic drug-drug interactions.
Pharmacodynamic pDDIs were further classified as: (a) synergistic or (b) antagonistic.
A key study that informed our recommendations was conducted by Garonzik et al., [17] who integrated population pharmacokinetic data with
pharmacodynamic data in a model to estimate dosing in critically ill patients with a wide range of renal function (including those receiving renal replacement therapy).
M's case, a
pharmacodynamic drug-drug interaction among citalopram, aspirin, and clopidogrel caused a GI bleed.
This study investigated the possible pharmacokinetic and/or
pharmacodynamic interaction of echinacea and policosanol with warfarin, in healthy subjects with a known CYP2C9 and VKORC1 genotype.
Therefore, it is important to predict the probabilities that biapenem regimens attain the
pharmacodynamic target (30% T > MIC)3 in PF against bacterial populations using a stochastic simulation, in order to rationalize and optimize the regimen for intra-abdominal infections.
"Platelet function tests suggest there is a
pharmacodynamic interaction between 400 mg of ibuprofen and low-dose aspirin when they are dosed concomitantly," the FDA said in a paper posted on its Med-Watch site on Sept.
High cure rates are possible with high-dose, short-course therapy when a potent, rapidly acting antibacterial agent is used, and
pharmacodynamic principles are applied.
"If you are planning to go out and screen the population for disease, obviously to qualify a test for that purpose is a very high bar because of the consequences versus a
pharmacodynamic assay that might be used in a drug development program," she explained.
Pharmacodynamic activity of telithromycin at simulated clinically achievable free-drug concentrations in serum and epithelial lining fluid against efflux (mefE)-producing macrolide-resistant Streptococcus pneumoniae for which telithromycin MICs vary.
* Drugs or substances modifying
pharmacodynamic response (e.g., alcohol, sedatives)
Pharmacodynamic and pharmacokinetic effects in gingival cervical fluid from redosing during the brushing cycle using an integrated power toothbrush/toothpaste dispensing system.