Dr Mark Calarco, Addiction Labs of America CEO, said, 'It's critical that we know how different people, based on their genetic makeup, process or metabolise cannabis or CBD, and that's information pharmacogenetic
testing could tell us.
"Over and over and over again, studies show that patients who have (particular) genetic defects have more toxicity, for example, than patients who don't," which could cause adverse reactions to a drug, said Relling, who studies the clinical application of pharmacogenetics
and investigates approaches to improving drug therapy for pediatric leukemia patients.
The choice of psychotropic medication is complex, and although we would like pharmacogenetics
to be the only answer to why every patient does or does not respond to a medication, it is not.
also plays an important role in polypharmacy with elderly patients by averting ADRs from drug-drug interactions.
The field of pharmacogenetics
can provide us with tools to deliver safer, more effective care and reduce the likelihood of adverse drug reactions."
Gupta noted, pointing to the Human Genome Project as a tool that can be used to help with pharmacogenetics
We firmly believe that the best approach for global pharmacogenetics
is to guide warfarin dosing by using a pharmacogenetic-based algorithm that also accounts for the effect of admixture or ancestry proportions.
This does not preclude an eventual role for pharmacogenetics
in the selection of analgesics.
The International Warfarin Pharmacogenetics
Consortium (IWPC) pharmacogenetic
algorithm is one of the high-performing and validated algorithms, recommended by the CPIC guidelines, with the aim to predict warfarin dose based on available information on genomic variation .
Acknowledgments: We acknowledge the critical input of members of the Clinical Pharmacogenetics
Implementation Consortium of the Pharmacogenomics Research Network, specifically Andrea Gaedigk, J.
According to the research done by Catherine Olivier, from University of Montreal's School of Public Health, from 1997 to 2003, there were 401 publications on pharmacogenomics identified in the PubMed database and 67 percent of them were published in a single journal, Pharmacogenetics
A number of genetic association studies examined SNPs as these are considered as the primary genetic determinants of the inter-individual variability in susceptibility to disease, response to treatment (pharmacogenetics
) and clinical outcomes (7-9).