pharmacokinetics

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pharmacokinetics

[¦fär·mə·kō·ki′ned·iks]
(pharmacology)
The study of the way that drugs move through the body after they are swallowed or injected.
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References in periodicals archive ?
A new pharmacokinetically enhanced formulation of amoxicillin/clavulanate (2,000/125 mg) has been developed to eradicate strains of PRSP with amoxicillin MICs as high as 4 [micro]g/ml.
It's better tolerated and pharmacokinetically easier to use.
In the last 10 years, pharmacokinetically guided administration of chemotherapeutic agents has become of increasing interest because the assessment of pharmacokinetic parameters such as AUC, drug CSS, and drug exposure time above a certain plasma concentration may lead to less toxicity and higher efficacy compared with administration on the basis of body surface area only.
A lot of women are going to pharmacies that compound testosterone gels or lozenges that have not been pharmacokinetically tested.
Therefore, 2 generic formulations may differ pharmacokinetically by more than a 4% difference if one product is on the low side of the BE limit and the other is on the high side.
These two pharmacokinetically determined human equivalent concentrations (HECs) or doses (HEDs), one for the mouse and one for the rat, were then compared to the corresponding HECs or HEDs obtained by the default methodology.
Drug Outcome Reference Gentamicin Pharmacokinetically controlled [4] dosing of gentamicin and of tobramycin in matched study patients achieved comparable rates of nephrotoxicity for these 2 antibiotics.
Pharmacokinetically guided dose escalation in phase I clinical trials was proposed by The European Organization for Research and Treatment of Cancer (EORTC) Pharmacokinetics and Metabolism Group to facilitate determinations of the maximum tolerated dose (MTD) for investigational anticancer drugs [15,16].