(redirected from phase II trial)
Also found in: Dictionary, Thesaurus, Medical, Legal.
Related to phase II trial: clinical test, double-dummy


procedure, in law, the rules that govern the obtaining of legal redress. This article deals only with civil procedure in Anglo-American law (for criminal procedure, see criminal law). Except for evidence, procedure conventionally embraces all matters concerning legal actions that come to trial; thus, procedure is the means for enforcing the rights guaranteed by the substantive law.

Current Civil Procedure

A legal action, in its simplest form, is a proceeding of a plaintiff against a defendant from whom redress is sought. The plaintiff begins a lawsuit by filing a complaint, a written statement of his or her claim and the relief desired, with a court that has jurisdiction (authority to hear the case). The defendant is served a process (e.g., a summons) that notifies him or her of the suit and usually responds with an answer. Failure to respond ordinarily entitles the plaintiff to a judgment by default.

Today, liberal rules of pretrial discovery allow parties to a civil action to obtain information from other parties and their witnesses through depositions and other devices. Discovery (i.e., disclosure) is now used to ascertain the facts believed by the other side to exist, and to narrow the issues to be tried. At common law, pleadings performed this function, and they were continued beyond the complaint and answer until an issue was agreed upon.

The issue is one of law if the defendant denies that the alleged acts are a violation of substantive law entitling the plaintiff to relief; it is one of fact if the defendant denies committing any of the alleged acts. The judge rules on an issue of law, and if the judge upholds the defendant the suit is dismissed. An issue of fact is resolved by the presentation of evidence to the jury, or, in cases tried without a jury, by the judge. After the jury has delivered a verdict on the factual issue, the judge renders a judgment, which in most (but by no means all) instances upholds the verdict. At this point the case is closed (unless the losing party prosecutes an appeal), and the plaintiff, if having won, proceeds to execution of the judgment.

Evolution of Procedural Law

Current procedural law has had a long historical evolution. The early common law allowed an action to be brought only if it closely conformed to a writ. Rigorous enforcement of the rule “no writ, no right,” and the small number of available writs acted to deny relief even in meritorious cases and stimulated the growth of equity, which, in its early days, gave redress generously.

By the 19th cent., however, the technical intricacy of equity and law procedure and the tendency to make cases hinge on procedural details rather than on substantive rights made reform imperative. The way was led by the New York code of civil procedure of 1848 (largely the work of David Dudley Field), which abolished the distinction between law and equity (thereby effecting great simplification) and established the cause of action as the procedural cornerstone. A similar reform was accomplished in Great Britain by the Judicature Acts of 1875. Today the procedure of most American jurisdictions is based on codes (like that of New York) rather than on common law and equity, although the influence of these separate categories is still frequently discernible.


See J. Michael, The Elements of Legal Controversy (1948); P. Carrington, Civil Procedure (1969).

The Columbia Electronic Encyclopedia™ Copyright © 2022, Columbia University Press. Licensed from Columbia University Press. All rights reserved.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a concept used in probability theory. Trials may have one (and only one) of the outcomes A1, A2,. . ., An Each outcome of a trial is considered an “event” that has a certain probability P(Ak). Here Trial always holds.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

What does it mean when you dream about a trial?

Dreaming of being on trial may indicate that the dreamer needs to be more accepting of himself or herself and less judgmental of others.

The Dream Encyclopedia, Second Edition © 2009 Visible Ink Press®. All rights reserved.


One of a series of duplicate experiments.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.


Bardell vs. Pickwick
trial for breach of promise results in imprisonment of both parties for not paying damages and costs. [Br. Lit.: Dickens Pickwick Papers]
Trial by Jury
trial of a breach-of-promise suit is dismissed when the judge decides to many the plaintiff. [Br. Opera: Gilbert and Sullivan Trial by Jury]
Trial, The
Joseph K. is tried by a strange court for an unspecified crime. [Ger. Lit.: Kafka The Trial]
Allusions—Cultural, Literary, Biblical, and Historical: A Thematic Dictionary. Copyright 2008 The Gale Group, Inc. All rights reserved.


1. Law
a. the judicial examination of the issues in a civil or criminal cause by a competent tribunal and the determination of these issues in accordance with the law of the land
b. the determination of an accused person's guilt or innocence after hearing evidence for the prosecution and for the accused and the judicial examination of the issues involved
c. (as modifier): trial proceedings
2. a motorcycling competition in which the skills of the riders are tested over rough ground
3. Ceramics a piece of sample material used for testing the heat of a kiln and its effects
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
MINNEAPOLIS--The investigational antisclerostin antibody AMG 785 increased bone mineral density up to 50%-60% more than did standard drugs used to treat low bone mineral density in postmenopausal women, judging from the findings of a phase II trial.
The phase II trial randomly assigned 419 postmenopausal women with low bone mineral density to one of five doses of subcutaneous AMG 785 (70 mg monthly, 140 mg monthly, 210 mg monthly, 140 mg every 3 months, or 210 mg every 3 months) or placebo, and one of two open-label active comparators: 70 mg weekly oral alendronate or 20 mcg daily subcutaneous teriparatide.
In a news release, the company described one of the phase II trials as "failed or inconclusive." In this trial, doses of 20 mg, 40 mg, and 80 mg of lurasidone daily were compared with 10 mg of haloperidol daily and placebo.
A phase II trial of erlotinib in combination with bevacizumab in patients with metastatic breast cancer.
-- Initiated head-to-head Phase II trial comparing CH-4051 to methotrexate (MTX) in rheumatoid arthritis patients who are experiencing an inadequate response to MTX treatment;
In this ongoing exploratory Phase II trial the safety and efficacy of a second dose of ATIR101 is being tested in patients to investigate product flexibility in administering a further dose of ATIR101 should it be needed by physicians.
The Phase II trial is are structured as a multicentred, randomised, double-blinded, placebo-controlled and dose-finding study.
The phase II trial is an active (enoxaparin)-controlled, dose-escalating, multicentre, prospective, randomised, open label trial evaluating TB-402 for the prophylaxis of DVT after knee replacement surgery.
This new data in the two pediatric HSCT-TMA patients follows prior positive preclinical and ex-vivo studies in two other TMAs, Antiphospholipid syndrome and atypical hemolytic-uremic syndrome; Coversin is currently being investigated by Akari in a Phase II trial in patients with aHUS.
NORDIC BUSINESS REPORT-6 January 2010-TopoTarget says belinostat enters phase II trial in USA(C)1994-2010 M2 COMMUNICATIONS
Known as MONOCLE, the Phase II trial is set to examine the efficacy of the drug tefinostat, in addition to investigating any myelomonocytic side effects that may arise in patients with chronic leukaemia (CMML).