The interaction in solution was studied by phase solubility analysis and dissolution experiments.
Phase solubility studies were performed in triplicate according to the method reported by Higuchi and Connors.
of the MLX was greatly improved from 12.5 ug/ml to 786.72 ug/ml (Figure 4).
. 2.5 x [10.sup.3] mol of ExMR, expressed as Hd, was suspended in 100 ml of water.
From literature search, six different carriers possessing P-gp inhibiting activity like Poloxamer 188, Kolliphor TPGS, Tween 80, Soluplus, Povidone (PVP K30), and Hypromellose (HPMC E5) were selected and were screened out by phase solubility
study to determine the most appropriate and suitable carrier.
Connors, "Phase solubility
studies," in Advances in Analytical Chemistry and Instrumentation, C.
To evaluate the effect of mobile phase solubility
in water bound to the cellulose fibers of W1 and W3MM papers during the separation of radioactive impurities and [[[sup.99m]Tc[(MIBI).sub.6]].sup.+], we used alcohols such as methanol, ethanol and 1-propanol, all completely soluble in water, and 1-butanol (0.9/10 mL), whose water solubility is similar to that of ethyl acetate (1/10 mL) (16).
Sinisterra, "Self-assembly characterization of the [beta]-cyclodextrin and hydrochlorothiazide system: NMR, phase solubility
, ITC and QELS," Journal of Inclusion Phenomena, vol.
From the viewpoint of stretch-blow molding, we studied the effect of the phase solubility
(compatibility) and crystallinity of PEN/PET blend resins on heat-setting after stretching, with special attention to the effects of these characteristics on stretch molding properties.
Higuchi, "Phase solubility
techniques," in Advances in Analytical Chemistry Instrumentation, vol.
The phase solubility
diagrams were obtained plotting the equilibrium concentrations of terbuthylazine against the concentration of the respective CD.
studies are widely used to evaluate the effect of CD on the water-solubility of drugs.