Finally, as a consequence of the solid-liquid phase transfer catalysis
method, these intermediates reacted with 2- chloroethyl alcohol to prepare the final new products 1-hydroxyethyl-2-substituted phenoxymethyl benzimidazoles (c1-c5) in high yield.
Following an introduction to the topic of process development, chapter topics include chiral technology, strategies to simplify organic reactions and processes, choosing a reagent, phase transfer catalysis
, purity and purification, and safety assessment.
Dehmlow, "Phase transfer catalysis
" Verlag Chemie, Basel 1983.
In order to achieve this objective the proposal brings together 3 partners with complementary skills: an expert in Phase Transfer Catalysis
, Organo-Catalysis and synthesis (RCSI), an expert in development of DNA based catalysis and DNA elaboration (University of Nottingham) and an expert in the manufacture of polymer bound biomolecules and drug intermediates (Prigen).
Jones, In The Quaternary Ammonium Salts Their Use in Phase Transfer Catalysis
, Academic Press, Trowbridge, 2001.
At the present time, the main catalysis systems are gas-liquid phase transfer catalysis
[15, 16], tetrabutylammonium bromide homogeneous catalysis  and NaX zeolite  heterogeneous catalysis.