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C12H12N2O3 A crystalline compound, 5-ethyl-5-phenylbarbituric acid, with a slightly bitter taste, melting at 174-178°C; soluble in water, alcohol, chloroform, and ether; used in medicine as a long-acting sedative, anticonvulsant, and hypnotic.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



(trade name, Luminal), a medicinal preparation of the barbiturate group. Taken in powder or tablet form, phenobarbital is a long-acting soporific and is used in the treatment of such conditions as epilepsy and vascular spasms. Phenobarbital may be combined, in tablet form, with various other substances, including analgesic and spasmolytic preparations (for example, Andipal, Camphodal, or Paluphin).

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
About 30 percent of dogs will achieve good seizure control on phenobarbital. Greater than 75 percent will have a significant reduction in seizure frequency.
In the history of a seven-month-old female patient who was admitted to the pediatric intensive care unit with a prediagnosis of phenobarbital intoxication, it was learned that she was recently followed up in the pediatric neurology ward because of seizures and her seizures were controlled with carbamazepine and phenobarbital.
In our study, use of phenobarbital was not associated with development of normal EEG compared with the control group.
Western blots were analyzed by a factorial 2 (saline or PTZ - "kindling") x 3 (saline, montelukast or phenobarbital - "treatment") x 2 (saline or PTZ - "challenge") ANOVA, followed by Bonferroni's test, and are reported as means [+ or -] SEM.
The patient had elevated ammonia and phenobarbital levels despite normal routine laboratory test results.
[6.] Holstein A, Plaschke A, Lohse P, Egberts EH: Successful photo- and phenobarbital the rapy during pregnancy in a woman with Crigler-Najjar syndrome type II.
In our patient, it consisted of using another antiepileptic drug instead of Phenobarbital. Second-line treatment is a vitamin therapy based on Niacin.
There were 94 infants who were randomly assigned, 50 to the phenobarbital group and 44 to the normal saline group (placebo).
Switch to Librium (chlor-diazepoxide) or phenobarbital in an outpatient setting at a time when patients are physiologically improved.
Phenobarbital increases the activity of GABA and decreases the activity of glutamate in the brain.
Phenobarbital at less than 150 mg/day was 2.5 times as risky as was low-dose lamotrigine, and phenobarbital at 150 mg/day or greater was 8.2 times as risky.
The FDA announced a voluntary, nationwide recall of certain lots of hydrocodone bitartrate and acetaminophen tablets and also certain lots of phenobarbital tablets.