Phenobarbital

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Related to phenobarbitone: phenytoin

phenobarbital

[¦fē·nō′bär·bə‚tȯl]
(pharmacology)
C12H12N2O3 A crystalline compound, 5-ethyl-5-phenylbarbituric acid, with a slightly bitter taste, melting at 174-178°C; soluble in water, alcohol, chloroform, and ether; used in medicine as a long-acting sedative, anticonvulsant, and hypnotic.

Phenobarbital

 

(trade name, Luminal), a medicinal preparation of the barbiturate group. Taken in powder or tablet form, phenobarbital is a long-acting soporific and is used in the treatment of such conditions as epilepsy and vascular spasms. Phenobarbital may be combined, in tablet form, with various other substances, including analgesic and spasmolytic preparations (for example, Andipal, Camphodal, or Paluphin).

References in periodicals archive ?
Type of medication N (%) Mean (SD) (b) Phenobarbitone 91 (52) 77.89 (20.68) Carbamazepine 15 (8.6) 83.54 (20.55) Phenobarbitone and valproate 23 (13.1) 71.12 (19.99) Phenobarbitone and carbamazepine 19 (10.9) 75.09 (24.06) Others 27 (15.4) 83 (18.89) Total (a) 175 (100) 77.97 (20.78) (a) Phenytoin, valproate, combination of phenytoin and valproate, and combination of CZP and phenytoin; (b) p value < 0.238 (not significant).
Effects of cadmium, lead and mercury on induction of hepatic microsomal drug metabolizing enzymes by phenobarbitone. Zhonggno Yao Lixue Yu Dulixue Zuzhi, 2: 61-65.
Because not all patients on phenytoin or phenobarbitone develop gingival overgrowth, identifying patients at risk is important in order to take necessary measures to minimize the onset and severity of this condition.
While the phenobarbitone induced sleeping time test is commonly employed for the assessment of hypnotic properties.
Codeine falls within Schedule III & phenobarbitone within Schedule IV.
Phenobarbital (previously known as phenobarbitone in the UK) belongs to a group of medicines called barbiturates.
Oxcarbazepine and carbomazepine had higher risk than phenytoin or phenobarbitone. Lamotrigine had the lowest risk, but the numbers were small for LTG and other newer antiepileptic drugs.
The antiepileptic drugs such as phenobarbitone, phenytoin and carbamazepine are known to produce cognitive deterioration as a side effect (66).
In 2008, police for the first time seized 50 kilograms of phenobarbitone in transit to Pakistan and 800 grams of methamphetamine in transit to Iran.
He explained that following this and other experiments, a drop of broad bean concentrate was examined by a form of chemical analysis (chromatography) and compared with drops of phenobarbitone (anticonvulsant drug), valium and glycine substance.
However, advances in medication in the 20th century - particularly the discovery of phenobarbitone in the 1920s - meant it was largely ignored for more than 100 years.