phenoxybenzamine hydrochloride

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phenoxybenzamine hydrochloride

[fə¦näk·sē′ben·zə‚mēn ‚hī·drə′klȯr‚īd]
(organic chemistry)
C18H22ONCl·HCl White crystals, slightly soluble in water, melting at 139°C; used in medicine.
References in periodicals archive ?
After 10 days of phenoxybenzamine and metyrosine, the patient was taken for combined coronary artery bypass grafting (CABG) and adrenalectomy.
After 3 weeks of phenoxybenzamine preparation, the patient was admitted to the hospital for 12 hours of intravenous fluid repletion.
5mg/tab and Phenoxybenzamine HCl 5mg/tab are available in this dosage form.
4] Preoperative management is essential to prevent hemodynamic instability and hypertensive crisis before or during surgery, which usually includes [alpha]-adrenergic blockade with phenoxybenzamine first and then [beta]-blockade, with sufficient hydration with intravenous fluids the night before surgery.
For more information on Phenoxybenzamine Hydrochloride Capsules USP, including the prescribing information, visit prasco.
Several other approaches have been used to increase the sensitivity or specificity of urinary metanephrines, including careful analysis of the patient's drug history (taking particular note of phenoxybenzamine, tricyclic antidepressants, and beta blockers) (12), absence of clonidine suppression of plasma NMT (12-14), use of overnight (12 h) testing to avoid the variability introduced by daytime physical activity and to increase specificity because of lower resting sympathetic activity overnight (15-17), special reporting for samples referred from intensive therapy units (18), and use of immunoassays for metanephrines to decrease drug interference (19).
Another approach to prevent perioperative spasm of the RA has been recently suggested by Taggart and co-workers and includes use of a non-selective [alpha]-adrenoceptor antagonist, like phenoxybenzamine.