Diclofenac is a phenylacetic acid
drug that has remarkable anti-rheumatic, anti-inflammatory, analgesic and antipyretic effects.
Compared with BP group, 23 metabolites were significantly altered in SD group: creatinine, azelaic acid, protocatechuic acid, and 3,4-dihydroxyhydrocinnamic acid were upregulated, yet lactate, glycolic acid, alanine, nicotinic acid, phenylacetic acid
, glycine, 4-deoxyerythronic acid, pipecolic acid, 2,4-dihydroxybutanoic acid, nicotinamide, uracil, threonic acid, suberic acid, putrescine, citric acid, hippurate, lysine, urate, and ascorbic acid were downregulated in SD group as shown in the heat map (Figure 5(a)).
In our work, rationale behind the selection of phenylacetic acid
and pyridine, is composition of [Cu(tmphen)2]Cl2, where tmphen stands for 3,4,7,8-tetramethyl-1,10-phenanthroline, the first reported copper complex with remarkable in-vivo anti-cancer activity and the Casiopeinas, a famous class of Cu(II) mixed-ligand complexes containing both N-and O-donor ligands [11, 12].
Meanwhile, obvious negative correlations were found in glycine and phenylacetic acid
compared with ALT and AST (Table 3).
The accumulation of phenyl-pyruvic acid also leads to formation and urinary excretion of Phenyllactic acid, o-hydroxyphenylacetic acid, and phenylacetic acid
, the last as phenylacetylglutamine (White et al., 1973).
In urinary organic acid analyses, it was observed that urinary excretion of adipic acid, succinic acid, glutaric acid, glycolic acid, 4-OH phenylacetic acid
and metylmalonic acid was normal, urinary excretion of 3-OH butiric acid, lactic acid and oxalic acid was slightly high and urinary excretion of fumaric acid was very high (Table 1).
Lately, we reported some of our findings on epoxidation of alkene using phenylacetic acid
The main reason is that it can catalyze the hydrolysis of Penicillin G in this compound and phenylacetic acid
Of the fourteen acids utilized by the recombinant ACSs in the work presented herein, nine of them (acetate, 3-methylthiopropionate, isobutyrate, isovalerate, 2-methylbutyrate, phenylacetic acid
, 4-hydroxyphenylacetic acid, indole-3-acetic acid, and succinate) result from the four KORs that have been characterized [10-12].
A series of Mannich bases of isatin and its derivatives with 2-[2,6-dichlorophenyl)amino] phenylacetic acid
11(a-f) (Figure 11) was synthesized.
More than 93% of all strains did not utilize also i-erythritol, L-rhamnose, D-sorbitol, D-galactonic acid lactone, D-gluconic acid, [gamma]-hydroxybutyric acid, p-hydroxy phenylacetic acid
, [alpha]-keto-valeric acid, quinic acid, saccharic acid, L-leucine, L-ornithine, L-phenylalanine, L-pyroglutamic acid, D-serine, thymidine, phenylethylamine, and putrescine and utilized [alpha]-D-glucose, L-fucose, and sucrose.
Themetabolism of chlorambucil occurs predominantly in the liver by the hepatic drug metabolising enzymes leading to the formation of 3-(4-dehydrochlorambucil and phenylacetic acid
mustard, 2-(4-(bis(2-chloroethyl)amino)phenyl)acetic acid) .