Although we found a statistically significant reduction in total vasopressor use in the colloid preloading group, we believe that the difference (approximately 150 [micro]g phenylephrine
) is not significant from a clinical perspective.
has high efficacy in increasing blood pressure, but it causes reflex bradycardia leading to decrease in cardiac output.
Keywords: Elective cesarean section, Fluid preload, Prophylactic phenylephrine
infusion, Rescue boluses, Spinal anesthesia.
Why should phenylephrine
be used in spinal hypotension?
The need for phenylephrine
and ephedrine (for the treatment of hypotension) and atropine (for the treatment of bradycardia) was higher in the placebo group.
Thirty minutes after adding [10.sup.-6] M phenylephrine
(see first set of experiments), aortic rings with intact endothelium were preincubated for 30 min with one (or two) of various compounds in order to explore the mechanisms involved in the vasorelaxant effect produced by clobenzorex.
A recent systematic review concluded that prophylactic phenylephrine
infusions reduced maternal hypotension, nausea and vomiting without altering other relevant maternal or neonatal outcomes.
In this paper we found that the muscarinic selective receptor antagonists were able to antagonize phenylephrine
tacrine activate-baroreflex mediated bradycardia.
We suspect that her transient hypertension and pupillary dilatation were caused by the systemic absorption and local spread of the topical phenylephrine
. Previous reports have documented isolated unilateral mydriasis precipitated by unintentional alpha-adrenergic drug exposure (1,2).
In this study the implementation of the technique of isolated vascular, the effects of time in the contraction of smooth muscle and the action of repeated dose of phenylephrine
in the sensibility of [alfa]1 receptors is presented.
infusion was started; however, hypotension remained refractory to fluid resuscitation and vasopressor therapy.
Although lime data exists to support clear clinical differences between pseudopehedrine and phenylephrine
, patients accustomed to the effects of pseudoephedrine could be experiencing a slight difference in efficacy when they switch to a phenylephrine-based product.