phenytoin


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phenytoin

[fə′nid·ə·wən]
(pharmacology)
C15H12N2O2 A powder with a melting point of 295-298°C; used as an anticonvulsant and antiepileptic in humans.
References in periodicals archive ?
Previously, children who continued seizing after phenytoin then needed to be intubated, sedated and placed on a ventilator in intensive care.
Phenytoin is an effective anticonvulsant that is used for partial and tonic-clonic seizures.
Male Wistar Albino rats (180-200 g, 6-9 weeks old) were used as the source of phrenic nerve-hemidiaphragm preparations (n=10 for topiramate and n=10 for phenytoin).
Phenytoin is a widely used non-sedative antiepileptic drug included in pregnancy category 'D' of teratogenic potential according to the FDA (United States Food and Drug Administration) which justifies the use of this drug if the potential therapeutic benefits outweigh the potential risks1.
The treatment retention rate at the end of follow-up period on carbamazepine was high compared to phenytoin, phenobarbitone, and valproic acid.
4, we can see that pgCAR is activated by Phenytoin and the dose response experiment was conducted to determine at what concentration phenytoin could significantly activate the pgCAR receptor in HepG2 cells.
The mean duration of stay for patients with diabetic foot using phenytoin topical application was 19 days, for the control group it was 25 days.
Regarding available data, phenytoin is a combined strong CYP3A4 and P-gp inducer, which might cause the reduction in rivaroxaban plasma levels.
In phenytoin and Vaseline group the mean baseline ulcer area decreased from 1310489.2 mm2 to 492.53460.9 mm2 at 8-weeks.
Whereas 36 of 50 patients in the group with no new seizures had serum phenytoin concentrations within the commonly accepted therapeutic range of 10-20 [micro]g/mL (Fig.
Plasma and gingival crevicular fluid phenytoin concentrations as risk factors for gingival overgrowth.
The common causes for Toxic Epidermal Necrolysis are medications that are taken for a short period of time, such as antibiotics co-trimoxazole, quinolones and cephalosporins or the medications used for prolonged period such as anticonvulsants like phenytoin, lamotrigene, carbamazepine etc.