phosphatidic acid

(redirected from Phosphatidate)
Also found in: Medical.

phosphatidic acid:

see phospholipidphospholipid
, lipid that in its simplest form is composed of glycerol bonded to two fatty acids and a phosphate group. The resulting compound called phosphatidic acid contains a region (the fatty acid component) that is fat-soluble along with a region (the charged phosphate
..... Click the link for more information.
.
The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/
References in periodicals archive ?
TG synthesis impairment was also associated with downregulation of two important enzymes of this pathway: 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 (AGPAT2) and the phosphatidate phosphatase LPIN1 (lipin1) in BSCL2 knockdown during adipogenesis [11, 45].
Brindley, "Unlike two peas in a pod: lipid phosphate phosphatases and phosphatidate phosphatases," Chemical Reviews, vol.
[29] Recently, the inhibitory effect of berberine has been reported on the liver phosphatidate phosphohydrolase (PAP) activity.
Yanagita, "Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats," Plant Foods for Human Nutrition, vol.
Reue, "Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns," Journal of Biological Chemistry, vol.
Most of these enzymes encountered little change in their expression levels, except for phosphatidate phosphatase (PP) and diacylglycerol acyltransferase (DGAT).
Regarding PA, it is an acid form of phosphatidate, a part of common phospholipids which are major components of cell membranes.
Lipin proteins act as [Mg.sup.2+]-dependent phosphatidate phosphatase (PAP) and catalyze the penultimate step of converting phosphatidic acid (PA) to diacylglycerol (DAG) in the glycerol phosphate pathway (Han et al., 2006; Donkor et al., 2007).
effect of garlic on liver phosphatidate phosphohydrolase and plasma lipid levels in hyperlipidemic rats.
L-NAME was previously reported to elevate circulating lipids [15-17] due to increased triglyceride synthesis through induction of hepatic phosphatidate phosphohydrolase (an enzyme essential in triglyceride synthesis) and decreased oxidation due to suppression of carnitine palmitoyltransferase I (CPT-1), and elevation of cholesterol secondary to lower bile acid synthesis due to suppression of hepatic cholesterol 7 alpha-hydroxylase (CYP7A1), the latter two genes being known targets for PPAR[alpha] [18,19].