phosphaturia


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phosphaturia

[‚fäs·fə′tu̇r·ē·ə]
(medicine)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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There, the S-Ca, S-P, total S-ALP, PTH, phosphaturia and calciuria were all normal, as was the wrist X-ray.
Hyperphosphatemia stimulates the posterior liberation of fibroblastic growth factor 23 (FGF23) by osteocytes, which inhibits proteins NaPilIa and NaPilIc in the proximal convoluted tubule generating phosphaturia. It also inhibits the activity of the 1a-hydroxylase renal enzyme, diminishing the synthesis of active vitamin D (1,25(OH)2D), leading to a reduction in the intestinal absorption of calcium and phosphorus, and seric levels of phosphorus.
According to the literature, in transgenic mice increased expression of Klotho in CKD was combined with adequate phosphaturia, better functional ability of the kidneys and significantly lower degree of calcification compared with wild-type mice with CKD and reduced production of Klotho (Ming Chang Hu et al., 2013a).
The other 2 patterns of proximal tubular damage are characteristically seen in patients with clinical Fanconi syndrome exhibiting type II renal tubular acidosis, phosphaturia, hyperuricemia, aminoaciduria, and glycosuria without hyperglycemia (those associated with cytoplasmic inclusions in proximal tubular cells and those with constipated lysosomes).
Klotho is a transmembrane protein that acts as an essential cofactor for FGF23 at its receptor but can also promote phosphaturia independently of FGF23 by inactivating NaPi-2a [43].
Niao Zhuo (MM) refers to chyluria, phosphaturia, filariasis, urinary system infection, urinary system cancer, tuberculosis, and so on.
Urine examination also revealed phosphaturia (P[O.sub.4] =35.5 mmol/24 hours) and calciuria ([Ca.sup.2+] = 17.4 mmol/24 hours).
The hypocalcemia causes a secondary hyperparathyroidism that leads to phosphaturia, demineralization of the bones, and eventually osteomalacia.
Both occur due to a complex cascade involving FGF-23 with reduction in phosphaturia and inhibition of 1-[alpha] hydroxylase.
Tenofovir causes Fanconi's syndrome characterised by proteinuria, phosphaturia, glycosuria (with normal blood glucose) and bicarbonate wasting.
Hypophosphatemia is the characteristic abnormality in these patients and is attributed to increased secretion of fibroblast growth factor 23 (FGF23), a phosphatonin secreted from dysplastic bone lesions, hence leading to phosphaturia (16).
Obstructions such as those mentioned cause kidney injury by increasing the pressure within the kidney collecting systems, resulting in a drop in the GFR, decreased water and sodium reabsorption, and phosphaturia (Talbot, 2008).