Essayan, "Cyclic nucleotide phosphodiesterases, " Journal
Adams, "PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling crosstalk, desensitization and compartmentalization, " Biochemical Journal, vol.
As the parent ligands were inactive, this study identifies the important role of Pd(II) centre in phosphodiesterase inhibition by Pd(II) complexes.
These results are in agreement with the previous study of Zheng et al., 2008, wherein the introduction of fluoro groups enhanced inhibitory potential of phenyl alkyl ketones against phosphodiesterase 4 (PDE4) .
Modulation of vascular cyclic nucleotide phosphodiesterases by cyclic GMP: role in vasodilatation.
Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta.
Identification of phosphodiesterase 4-modulated proteins secreted from lipopolysaccharide-stimulated Raw 264.7 macrophages
Phosphodiesterase 4 inhibitors such as roflumilast have been shown to inhibit the release of several inflammatory cytokines and chemokines in LPS-stimulated macrophages.
Further, Giembycz suggested that [beta]2-adrenoceptor desensitization is based on the accelerated degradation of cAMP by phosphodiesterase
The nitric oxide/cyclic guanosine monophosphate signaling pathway and enzymes related to that pathway, such as phosphodiesterase
type-5 (PDE-5), seem to play an important role in the relaxation of the smooth muscle of the LUT.
Duman, "Regulation of cAMP-specific phosphodiesterases
type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons," Journal of Neurochemistry, vol.
Except for assays with the phosphodiesterase
inhibitor IBMX (see Results section below), we counted these larvae as metamorphosed.