phosphofructokinase


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phosphofructokinase

[‚fäs·fə‚fru̇k‚tō′kī‚nās]
(biochemistry)
A glycolytic enzyme that functions in carbohydrate metabolism by catalyzing the phosphorylation of fructose phosphate.
References in periodicals archive ?
Staal, "Phosphofructokinase and pyruvate kinase in mouse embryonal carcinoma P19 cells in relation to growth and differentiation," Differentiation, vol.
(2013) investigated much longer sprint durations, finding that 6 weeks of cycling RSH (18 sessions of 4-9 x 30 s sprints) training in healthy males improved muscle phosphofructokinase activity and anaerobic threshold to a greater level than a matched training load performed in normoxia.
For example, in Crassostrea virginica phosphofructokinase and pyruvate kinase change from catabolic function in winter to anabolic function in summer (Greenway & Storey 2000).
This is related to the high K requirement for operation of certain regulatory enzymes, especially pyruvate kinase and phosphofructokinase. On the other hand, the starch synthase, which catalyses the transfer of glucose into starch molecules, is highly dependent on monovalent cations, including K, which is the most efficient (MARSCHNER, 2011).
The protective effect of free and bound polyphenols extracts from ginger has been seen on hepatic antioxidants and some carbohydrate metabolizing enzymes (hexokinase and phosphofructokinase) in STZ-diabetic rats (Kazeem et al., 2013).
The mechanism of action of these agents is suppression of the phosphofructokinase (PFK) activity resulting in blocked ATP production.14 Trivalent antimony components were used but they were replaced with pentavalent antimony in 1920's because of severe renal and cardiac side effects.
Fructose-1,6-diphosphatase, phosphofructokinase and glucose-6-phosphate dehydrogenase from fermenting and non fermenting yeasts.
During glycolysis, we have a reaction catalyzed by phosphofructokinase: fructose-6-phosphate + ATP [right arrow] fructose-1,6-bisphosphate + ADP.
A new enzyme with the glycolytic function of 6 phosphofructokinase," Journal of Biological Chemistry, vol.
Fructose bypasses the two highly regulated steps of glycolysis, catalyzed by glucokinase/hexokinase and phosphofructokinase. Instead, fructose enters the pathway at a level that is not regulated and excessive fructose metabolism leads to the direct activation of ROS through NADPH oxidase [43].
In glycolysis, [P.sub.i] is a substrate for glyceraldehyde-3-phosphate dehydrogenase and stimulates the activities of hexokinase and phosphofructokinase.

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