phospholipase A2


Also found in: Medical, Acronyms, Wikipedia.

phospholipase A2

[‚fäs·fə′lī‚pās ¦ā′tü]
(biochemistry)
A principal phospholipase that cleaves fatty acids (principally arachidonic acid) from the second position (F2) of phospholipids. Abbreviated PLA2.
References in periodicals archive ?
Darapladib, a reversible lipoprotein-associated phospholipase A2 inhibitor, for the oral treatment of atherosclerosis and coronary artery disease.
Among non-enzymatic proteins super families of three finger toxins serine proteinase inhibitors C-type lectin related proteins artrial nutrient peptides and never growth factors have already been well characterized LAAO phospholipase A2 metalloprotease are some examples of super familie of enzyms.
Cardiotoxicity of Naja nigricollis phospholipase A2 is not due to alterations in prostaglandin synthesis.
An in-vitro study revealed that the cardiotoxin from cobra venom caused disintegration of the membrane structure of human erythrocytes, which potentiates the hydrolysis of phospholipids in the membrane by the phospholipase A2.
A second clinical-stage program targets inflammatory disorders by inhibiting cytosolic phospholipase A2 (cPLA2).
We then determined the importance of inflammation by showing that these diet-induced changes could be reversed by novel compounds including KH064 (secretory phospholipase A2 inhibitor), (24) 3D53 and SB290157 (complement receptor antagonists) (25) and GB88 (PAR2 antagonist) (26) that selectively target inflammatory mechanisms.
Patatin-like phospholipase domain containing 8 (PNPLA8) belongs to membrane-associated calcium-independent phospholipase A2.
When arteries become inflamed, the vulnerable plaques also produce an enzyme known as lipoprotein-associated phospholipase A2 (Lp-PLA2).
com)-- Peter Adamson, Vice President and Head of Research and Ophthalmology at GlaxoSmithKline will give a featured presentation on “Lipoprotein-associated Phospholipase A2 Inhibition Regulates Retinal Vasopermeability During Experimental Diabetes” at GTCs 5th Ocular Diseases and Drug Development Conference to be held in San Francisco, CA on March 21-22, 2013.
But the AACE encourages looking at the inflammatory markers highly sensitive C-reactive protein (hsCRP) and in some patients lipoprotein-associated phospholipase A2 (Lp-PLA2), when risk is uncertain and additional information is needed to decide how aggressively to treat.
The enzymes include cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and Phospholipase A2 (PLA2).
Key WORDS: air pollution, atherosclerosis, epidemiology, inflammation, lipoprotein-associated phospholipase A2, myocardial infarction, panel study.
Full browser ?