phospholipase C


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Related to phospholipase C: Phospholipase A2

phospholipase C

[‚fäs·fə′lī‚pās ¦sē]
(biochemistry)
A widely distributed enzyme of considerable physiological significance that hydrolyzes phospholipids at the phosphodiester bond to produce diacylglycerol and a phosphorylated head group, as found in phosphocholine or phosphoinositol. Abbreviated PLC.
References in periodicals archive ?
Because M119 blocked phospholipase C and previous studies had suggested that phospholipase C blunts morphine's pain relief, the researchers tested M119's effect on the morphine-triggered pathway.
Phospholipase D (PLD) releases the head group from phosphatidic acid; phospholipase C cleaves the head group and the sn-3 phosphate from diacylglycerol (DAG), which usually is rapidly phosphorylated by DAG-kinase (Lundberg and Sommarin, 1992) to form phosphatidic acid.
Because of its calcium-releasing role in some other cells, an enzyme called phospholipase C (PLC) was among the suspects.