picolinic acid


Also found in: Dictionary, Medical, Wikipedia.
Related to picolinic acid: nicotinic acid, pipecolic acid

picolinic acid

[¦pik·ə¦lin·ik ′as·əd]
(organic chemistry)
C10H8N4O5 An alcohol-soluble crystalline compound, forming yellow leaflets that melt at 116-117°C; used as a reagent in phenylalanine, tryptophan, and alkaloids production, and for the quantitative detection of calcium.
Mentioned in ?
References in periodicals archive ?
Hamilton, "Antiviral, cytotoxic and apoptotic activities of picolinic acid on human immunodeficiency virus-1 and human herpes simplex virus-2 infected cells," Anticancer Research, vol.
Varesio, "Regulation of nitric-oxide synthase mRNA expression by interferon-[gamma] and picolinic acid," The Journal of Biological Chemistry, vol.
Beninger, "Action of picolinic acid and structurally related pyridine carboxylic acids on quinolinic acid-induced cortical cholinergic damage," Brain Research, vol.
Beninger, "Picolinic acid protects against quinolinic acid-induced depletion of NADPH diaphorase containing neurons in the rat striatum," Brain Research, vol.
Beninger, "Picolinic acid modulates kainic acid-evoked glutamate release from the striatum in vitro," Brain Research, vol.
Iwata, "Is picolinic acid a glycine agonist at strychnine-sensitive receptors?" Brain Research, vol.
Preparation of solutions: Stock solutions (10 mg [ml.sup.-1]) of L-tryptophan, nicotinic acid, picolinic acid and nicotinamide were prepared in water, and benznidazole and nifurtimox were prepared in 10% DMSO (v [v.sup.-1]).
Antitrypanosomal activity: Epimastigotes of M5-2 strain in logarithmic growth phase (5 x [10.sup.5] cells) were added to 18 x 180 mm screw-capped tubes containing 2 mL of growth medium with 10 or 50 [micro]g [ml.sup.-1] picolinic acid added.
The medium containing different concentrations of picolinic acid (1200 - 1.12 [micro]g [ml.sup.-1]) were added to each well containing the cells, and the plates were incubated for 96h.
Effect of L-tryptophan, nicotinic acid and nicotinamide on picolinic acid inhibitory activity: The experiments using epimastigote and trypomastigote forms were performed as above, except that L-tryptophan, nicotinic acid and nicotinamide were added (100 [micro]g [ml.sup.-1] final concentration) aseptically to the growth medium or phosphate buffer containing 50 [micro]g [ml.sup.-1] picolinic acid.
In this study, we also examined the effect of picolinic acid on the growth of epimastigote forms and the motility of trypomastigote forms of M5-2 strain of Schizotrypanum trypanosomes isolated from bat Phyllostomus hastatus.
The number of motile trypomastigotes decreased (50%) after 6h in the presence of 50 [micro]g [ml.sup.-1] picolinic acid, and after 24h no motile trypomastigotes were observed.