In postsynaptic buccal cells, B34 and B40 produce chloride-mediated rapid inhibitory postsynaptic potentials (IPSPs) that are desensitized by GABA and the [GABA.sub.A] agonist muscimol, blocked by the [GABA.sub.A] antagonists picrotoxin
and bicuculline, and augmented by the GABA uptake inhibitor nipecotic acid (Jing et al., 2003).
For experiments with picrotoxin
and A[beta] oligomers, hippocampal slices were placed in the recording chambers soon after this recovery period.
After induction of anesthesia, the animals were transferred to aquaria with anesthetic-free water (n=8) or to aquaria containing 100 mg/L picrotoxin
(n=8) to measure their partial recovery (response of fish to pressure stimulus on the caudal peduncle with a glass rod) and total recovery (normal swimming with response to external stimulus) time.
Abbreviations: AC: amacrine cell; BC: bipolar cell; CI: the correlation index; Fs GC: Fast-sustained GC; Ft GC: Fast-transient GC; GABA: [gamma]-amino butyric acid; GC: ganglion cell; MFQ: mefloquine; Ms: Medium-sustained GC; Mt GC: Medium-transient GC; PCA: the principal component analysis; PSTH: the peri-stimulus time histogram; PTX: picrotoxin
; RCC: the raw cross-correlogram; RF: the receptive field; SC: the shift predictor correlogram; Ss GC: Slow-sustained GC; STA: the spike-triggered average; St GC: Slow-transient GC; V1: primary visual cortex.
The negative control group: mice received the amount of 10 ml/kg normal saline 20 min before picrotoxin
Epileptiform activity recordings: Artificial cerebro spinal fluid (ASCF) containing the GABAa receptor blocker picrotoxin
(100 [micro]M) was bath applied and the same was used in electrodes.
GluCls are activated by the glutamate analog, ibotenic acid, and are inhibited weakly by the ligand-gated chloride channel blocker, picrotoxin
(Smith et al.
(2010) screened for RDX binding to different neurological receptors and found that RDX binds to the picrotoxin
binding site in the chloride channel of the [gamma]-aminobutyric acid A (GABAA) receptor, an interaction associated with the onset of seizures in rats.
The goal of this project is to determine if picrotoxin
has an effect in the supraesophageal ganglion (the location of the secondary and tertiary auditory interneurons) of female Acheta domesticus.
The first group was designated as control group; and the second as the picrotoxin
(10mg/kg; intraperitoneal) alone group.
Administration of the GABA antagonist picrotoxin
after extinction training enhanced prolonged extinction.
apigenin significantly shortened the latency period of picrotoxin
induced fits but did not reduce the incidence of seizures.