Studies in the 1970s showed that germ-free mice (66) or mice receiving "gut-decontaminating" nonabsorbable antibiotics (a combination of neomycin, streptomycin, bacitracin, and pimaricin
) (65) experienced less frequent or attenuated GVHD.
Further, they found Clotrimazole as drug of choice based on antifungal drug sensitivity testing against fungal isolates from bovine mastitis which was followed by Itraconazole, Ketoconazole and Pimaricin
. They reported resistance to Fluconazole and Griseofulvin.
Infected tissues of collected leaves (single lesion) from each locality were placed in petri-dishes containing rye agar medium amended with antibiotic 100 L/mL vancomycin 100 L/mL pimaricin
and 50 L/mL rifamycin (Caten and Jinks 1968).
These antibiotics are: pimaricin
, ampicillin, rifampicin, pentachloro-nitrobenzene (PCNB), and hymexazole (Kannwischer and Mitchell, 1978).