Neurohypophysial GCT originated from the pituicytes which are modified as gliocytes of ependymal cell lineage located in the neurohypophysis and pituitary stalk.
However, the positive staining of GFAP was controversial though it normally expressed in the pituicytes. The best way to make differential diagnosis between pituicytoma and GCT was that there were no Rosenthal filaments and eosinophilic granules in pituicytoma.
Light micrograph of the pars nervosa in hypophysis: A-F: hypophyseal cleft (HypC), pars intermedia (PaI), pars nervosa (PN), protoplasmic pituicyte (PP), fibrous pituicyte (FP), herring body (HB), unmyelinated nerve fiber (Unf).
They contained large numbers of unmyelinated nerve fibres, pituicytes, rich in capillaries and connective tissue.
True plurihormonal adenomas with unusual combinations of hormonal types are uncommon (see algorithm, Figure 2) and the pathologist should always reexamine the specimen in such cases to exclude the possibility of entrapped normal anterior pituicytes
, some of which can occasionally be found at the edges of adenoma fragments, admixed with and surrounded by adenoma cells.
Bloom et al., "Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes
," Surgery, vol.
Compared to the intermediate lobe (IL), an intense vimentin-IR was observed in the hypophysis nervous lobe (NL) with the labelling of filamentous structures identified as pituicytes
Pituicytoma is a distinct low-grade glioma arising from pituicytes
of the neurohypophysis and infundibulum.
By their morphology and immunostaining pattern, pituicytomas are thought to arise from pituicytes
, specialized glial cells of the neurohypophysis.
The posterior lobe of the pituitary gland or neurohypophysis contains unique glial elements referred to as pituicytes
. These cells play a supportive role for the axons of large vasopressin and oxytocin-producing neurons whose cell bodies reside in the hypothalamus. Among neoplasms that arise from the neurohypophysis, intrasellar granular cell tumors are best known and may originate from pituicytes
. In addition, very rare low-grade spindle cell tumors,[3-6] claimed to represent pituicytomas and thought to arise from pituicytes
, are encountered along the neurohypophysis.
The neurohypophysis is composed primarily of pituicytes
, nerve fibers, axon terminals, and Herring bodies.