Qian et al., "Apoptosis in nontumorous and neoplastic human pituitaries
: expression of the Bcl-2 family of proteins," The American Journal of Pathology, vol.
Our study showed that the pituitaries kept their "memory" of the events triggered by LPS exposure, and this affected AP explants activity during in vitro culture.
The effect of IL-1[beta] treatment on LH release was stronger in pituitaries collected from LPS-treated ewes LH release in APs from LPS-treated ewes from the beginning of the experiment.
We found that nestin expression was evidenced only in the adenomatous pituitaries and correlated positively with the percentage of small vessels and negatively with years since the first diagnosis of pituitary adenoma .
Prominent vascular channels, as well as extravasated red blood cells not contained in capillaries or peliosis, are common findings in the hyperplastic and adenomatous [Drd2.sup.-/-] pituitaries. Peliosis has been found in different tumors that secrete VEGF.
In the pituitaries from control rats at all time points after DEN administration, most of the granular cells were of the storage type, characterized by many secretory granules and an inactive appearance, with poor development of endoplasmic reticula (ER) and Golgi complex (Figure 1), as described in detail by others (13,37).
The pituitaries from DEN-treated female rats on day 7 showed changes similar to those in the pituitaries in the males at the same time point, and on day 35 the pituitaries looked normal.