Intravascular ultrasound exhibited progressed atherosclerosis at the culprit site, but no plaque rupture
was detected in our case.
Together, they have been shown to slow and even reverse plaque accumulation, while boosting the stability of deadly soft plaque to help prevent a plaque rupture
is characterized by intraluminal thrombus on a disrupted thin fibrous cap overlying a necrotic core with infiltration of macrophages whereas plaque erosion manifests as thrombus on an intact fibrous cap with less or deep-seated necrotic core.
(9) Pre-existing mast-cells within the coronary arteries release proteases upon activation during an anaphylactic event, leading to degradation of extracellular matrix around a plaque site, ultimately contributing to plaque rupture
Pro-inflammatory inducible cyclooxygenase-2/mPGES-1 are overexpressed in symptomatic plaques in association with PGE2-dependent MMP biosynthesis and release leading to plaque rupture
.[sup] EP4 immunoreactivity was strong in 4 PGE2 receptors EP1-4 expression of plaques from symptomatic and asymptomatic patients undergoing CEA.
Atherosclerosis starts early in life and it leads to plaque rupture
. The whole process starts with lipid deposition which leads to inflammation and then thrombosis.
Yoshida et al., "Non-invasive assessment of plaque rupture
by 64-slice multidetector computed tomography--comparison with intravascular ultrasound," Circulation Journal, vol.
For example, culprit plaque rupture
and thin-cap fibroatheroma (TCFA) are more prevalent in STEMI patients compared to patients with stable angina, for example.
was identified by the presence of disrupted fibrous cap .
COPD exacerbations may represent a time of intense oxidative stress and systemic inflammation that drive endothelial dysfunction, vascular reactivity, and even atherosclerotic plaque rupture
In the meantime, decrease in the thickness of fibrous cap at the injury site raises the risk of plaque rupture
and may result in death by inducing CAD.17 Biologically speaking, MMP- 9 exerts catalytic action depending on the active center Zn2+.
Instead, the amount of coronary atherosclerosis, together with the number of risk factors that encourage plaque rupture
, are better predictors of heart attack, they say.