Plasma Substitute

(redirected from plasma expander)
Also found in: Medical.

Plasma Substitute

 

a fluid that exerts the same mechanical and oncotic effects as whole blood or plasma but—unlike plasma—does not have clotting capacity or the ability to undergo an immune response.

References in periodicals archive ?
We are the first company which has produced starch-based plasma expanders, which is called "HAES-STERIL".
The study was conducted on hamsters, which were hemorrhaged into shock and then assigned to separate resuscitation groups: shed blood, a non-oxygen- carrying plasma expander (hydroxyethyl starch, HES), and MalPEG-Hb.
The presentation will also include a review of the company's plasma expander products.
PentaLyte is BioTime's proprietary pentastarch-based synthetic plasma expander and is being tested in cardiac surgery in a prospective, randomized, double-blind controlled study.
PentaLyte is BioTime's proprietary pentastarch-based synthetic plasma expander similar in formulation to Hextend, designed especially for use when faster elimination of the starch component is medically desired.
The current discussion between the FDA and Centeon is mainly focused on the list of Centeon's products manufactured in its Kankakee, Illinois facility which can be identified as "medically necessary" -- particularly the plasma expander Albuminar.
Hextend's growing use and acceptance in leading hospitals throughout the United States, its selection as the plasma expander of choice for the pre-hospital treatment of battlefield injuries overseas by the United States Army Medical Department, its upcoming launch in Canada, combined with CJ's leadership in the Korean pharmaceutical market will facilitate Hextend's emergence as its premium plasma expander.
In the experiments, six of nine rats which were resuscitated with the plasma expander and treated with 100% oxygen at two atmospheres above normal atmospheric pressure survived long term.
It is the only plasma expander approved in the United States that contains 6% hetastarch in lactated electrolyte injection.
The studies show that BioTime's plasma expander can allow resuscitation without subsequent blood transfusion in rats despite extended periods of hemorrhagic shock and respiratory arrest caused by an otherwise lethal loss of half their circulating blood volume.
Other experiments indicated that rats could survive loss of nearly all their blood if, as they lost blood, it was replaced with plasma expander.
BioTime's plasma expander is one of the fluids tested in both of these studies.