tissue plasminogen activator

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Related to plasminogen activator: streptokinase, Plasminogen activator inhibitor

tissue plasminogen activator

[¦tish·ü plaz‚min·ə·jən ′ak·tə‚vād·ər]
(medicine)
A proteolytic enzyme that can convert plasminogen to plasmin.
References in periodicals archive ?
Association of tissue plasminogen activator and plasminogen activator inhibitor polymorphism with myocardial infarction: a meta-analysis.
Efficacy and safety of tissue plasminogen activator 3 to 4.
PAION has initiated early-stage development activities for a series of plasminogen activators and analogues that make use of the exciting pre-clinical findings of Desmoteplase.
6) More recent studies employed recombinant tissue plasminogen activator (tPA).
Currently in the United States, a drug called recombinant tissue plasminogen activator (rt-PA) is approved for treating strokes which have been caused by clots blocking blood flow to the brain.
Randomized trial of intra-arterial recombinant tissue plasminogen activator, intravenous recombinant tissue plasminogen activator and intra-arterial streptokinase in peripheral arterial thrombolysis.
Similarly, in a cost-effective analysis of thrombolytic therapy with tissue plasminogen activator (t-PA) compared to streptokinase, the authors conclude, "The cost-effectiveness of treatment with accelerated t-PA rather than streptokinase compares favorably with that of other therapies whose added medical benefit for dollars spent is judged by society to be worthwhile.
THR-18, a synthetic therapeutic peptide derived from plasminogen activator inhibitor-1 (PAI-1) is currently being studied in a Phase II clinical trial in stroke patients treated with the clot buster drug, tissue plasminogen activator (tPA).
The urokinase plasminogen activator receptor (uPAR), [3] which consists of 3 domains (domains I, II, and III), is an extracellular protein anchored to the plasma membrane via a glycosylphosphatidylinositol moiety located on domain III (4).

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