platelet-derived growth factor


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platelet-derived growth factor

[¦plāt·lət də‚rīvd ′grōth ‚fak·tər]
(cell and molecular biology)
A glycolytic protein released by platelets and other cells that stimulates growth of cells of mesenchymal origin, for example, bone cartilage, vascular tissue, and connective tissue.
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References in periodicals archive ?
Amplification: If the platelet-derived growth factor receptor-[alpha]/CEP4 signal ratio was [greater than or equal to]2, it was evaluated as amplification (9).
Ross, "Platelet-derived growth factor in vivo: levels, activity, and rate of clearance," Blood, vol.
Rezende, "Evaluation of the effect of calcium gluconate and bovine thrombin on the temporal release of transforming growth factor beta 1 and platelet-derived growth factor isoform BB from feline platelet concentrates," BMC Veterinary Research, vol.
To culture the extracted SHEDs in vitro, fetal bovine serum (FBS) is the most commonly used culture supplement for MSCs, with multiple nutrition and growth factors, such as platelet-derived growth factors (6), insulin-like growth factors I and II (7), and TGF-[beta] (8).
Transcription of platelet-derived growth factor receptor a in Leydig cells involves specificity protein 1 and 3.
Platelets release large amounts of platelet-derived growth factor (PDGFaa, PDGFbb, and PDGFab), transforming growth factor beta (TGF[beta]1 and [beta]2), EGF, and VEGF.
Various proteins have been suggested as markers for CAFs, including [alpha]-smooth muscle actin (SMA) [3], tenascin-C [4], chondroitin sulfate proteoglycan (NG2) [5], platelet-derived growth factor receptor (PDGFR)[alpha]/[beta] [6], fibroblast activation protein (FAP) [7], podoplanin [8], prolyl 4-hydroxylase [9], and fibroblast-specific protein- (FSP-) 1 [5].
and believe this product, as well as the PDGF (platelet-derived growth factor technology) platform, will be important drivers of the long-term growth of our business for years to come."
AR-13154 targets Rho Kinase, Janus Kinase 2, and platelet-derived growth factor receptor beta.
and believe this product, as well as the PDGF (platelet-derived growth factor) technology platform, will be important drivers of the long-term growth of our business for years to come."
Immunohistochemical studies were strongly positive for CD34 and bcl-2, mildly positivefor phosphorylated protein kinase B and phosphorylated extracellular signal-regulated kinase 1/2, and negative for platelet-derived growth factor receptor alpha and p53.

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